Evidence map›Paper›PMID 32621364›Full record

ArticleHuman brain mapping2020

Mesoscale diffusion magnetic resonance imaging of the ex vivo human hippocampus.

Maria Ly, Lesley Foley, Ashwinee Manivannan, T Kevin Hitchens, R Mark Richardson, Michel Modo

Abstract read
In one paragraph

Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Article
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  7. Article
  8. Diffusion MRI of the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  9. Article
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  11. Article
  12. Article
  13. Article
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  15. Physical therapy exerts sub-additive and suppressive effects on intracerebral neural stem cell implantation in a rat model of stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maria LyDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lesley FoleyDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ashwinee ManivannanDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
T Kevin HitchensDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
R Mark RichardsonDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-2620-7387
Michel ModoDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-4436-735X

Funding

Mesoscopic Diffusion-based MRI Histology of Epileptic Human HippocampiR21NS088167 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MODO, MICHEL M. · 2015 to 2016
$399k
NINDS NIH HHS R21 NS088167
6 · The paper itself

Abstract

Mesoscale diffusion magnetic resonance imaging (MRI) endeavors to bridge the gap between macroscopic white matter tractography and microscopic studies investigating the cytoarchitecture of human brain tissue. To ensure a robust measurement of diffusion at the mesoscale, acquisition parameters were arrayed to investigate their effects on scalar indices (mean, radial, axial diffusivity, and fractional anisotropy) and streamlines (i.e., graphical representation of axonal tracts) in hippocampal layers. A mesoscale resolution afforded segementation of the pyramidal cell layer (CA1-4), the dentate gyrus, as well as stratum moleculare, radiatum, and oriens. Using ex vivo samples, surgically excised from patients with intractable epilepsy (n = 3), we found that shorter diffusion times (23.7 ms) with a b-value of 4,000 s/mm

Indexed as

Diffusion Magnetic Resonance ImagingAgedAnterior Temporal LobectomyDentate GyrusDiffusion Tensor ImagingEpilepsy, Temporal LobeFemaleGray MatterHippocampusHumansMaleMiddle AgedNerve NetPerforant PathwayPyramidal Cellsconnectomediffusion tensor imagingepilepsyex vivohippocampusmesoscaletractography

Identifiers

PMID32621364
PMCPMC7502840

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.