Evidence map›Paper›PMID 32621339›Full record

ArticleJournal of medical primatology2020

SARS-CoV-2 surveillance for a non-human primate breeding research facility.

JoAnn L Yee, Koen K A Van Rompay, Amanda B Carpenter, Peter B Nham, Bryson M Halley, Smita S Iyer, Dennis J Hartigan-O'Connor, Christopher J Miller, Jeffrey A Roberts

Open access · bronzeAbstract read
In one paragraph

Article in Journal of medical primatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.3field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

JoAnn L YeePrimate Assay Laboratory, California National Primate Research Center, University of California, Davis, California, USA.ORCID 0000-0002-5514-9836
Koen K A Van RompayPrimate Assay Laboratory, California National Primate Research Center, University of California, Davis, California, USA.ORCID 0000-0002-7375-1337
Amanda B CarpenterPrimate Assay Laboratory, California National Primate Research Center, University of California, Davis, California, USA.
Peter B NhamPrimate Assay Laboratory, California National Primate Research Center, University of California, Davis, California, USA.
Bryson M HalleyPrimate Assay Laboratory, California National Primate Research Center, University of California, Davis, California, USA.
Smita S IyerPathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, USA.ORCID 0000-0002-8918-7005
Dennis J Hartigan-O'ConnorMedical Microbiology and Immunology, School of Medicine, University of California, Davis, California, USA.ORCID 0000-0003-4822-636X
Christopher J MillerPathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, USA.ORCID 0000-0002-1381-1975
Jeffrey A RobertsPrimate Assay Laboratory, California National Primate Research Center, University of California, Davis, California, USA.
Primate Conservation · USUniversity of California, Davis · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Viral Testing CoreU42OD010990 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KOEN K VAN ROMPAY · 2012 to 2026
$20.1M
Role of female genital mucosa associated CD4 T cells in vaccine-induced HIV susceptibilityR21AI143454 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IYER, SWAMINATHAN SMITA · 2019 to 2020
$623k
NIAID NIH HHS R21 AI143454NIH HHS 5U42OD010990NIH HHS P51 OD011107NIH HHS P51 OD011107-59NIH HHS R21 AI143454-02S1NIH HHS U42 OD010990
6 · The paper itself

Abstract

backgroundThe emergence of SARS-CoV-2 and the ensuing COVID-19 pandemic prompted the need for a surveillance program to determine the viral status of the California National Primate Research Center non-human primate breeding colony, both for reasons of maintaining colony health and minimizing the risk of interference in COVID-19 and other research studies.

methodsWe collected biological samples from 10% of the rhesus macaque population for systematic testing to detect SARS-CoV-2 virus by RT-PCR and host antibody response by ELISA. Testing required the development and validation of new assays and an algorithm using in laboratory-developed and commercially available reagents and protocols. RESULTS AND

conclusionsNo SARS-CoV-2 RNA or antibody was detected in this study; therefore, we have proposed a modified testing algorithm for sentinel surveillance to monitor for any future transmissions. As additional reagents and controls become available, assay development and validation will continue, leading to the enhanced sensitivity, specificity, accuracy, and efficiency of testing.

Indexed as

AnimalsAntibodies, ViralBetacoronavirusCoronavirus InfectionsCOVID-19FecesHumansMacaca mulattaMonkey DiseasesPandemicsPneumonia, ViralRNA, ViralSARS-CoV-2Sentinel SurveillanceAntibodies, ViralRNA, ViralantibodyCOVID-19management practicesRNA PCRtesting algorithm

Identifiers

PMID32621339
PMCPMC7361642
OpenAlexW3040651769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.