ArticleMagnetic resonance in medicine2020
Fast whole brain MR imaging of dynamic susceptibility contrast changes in the cerebrospinal fluid (cDSC MRI).
Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Ultrafast Blood TMagnetic resonance in medicine · 2026Article
- Imaging the distribution and drainage of fluid in the human olfactory regions using intravenous Gadolinium-based contrast agents (GBCA) enhanced MRI.Fluids and barriers of the CNS · 2025Article
- Review
- Rapid imaging of intravenous gadolinium-based contrast agent (GBCA) entering ventricular cerebrospinal fluid (CSF) through the choroid plexus in healthy human subjects.Fluids and barriers of the CNS · 2024Article
- Characterizing cerebrospinal fluid mobility using heavily T2-weighted 3D fast spin echo (FSE) imaging with improved multi-directional diffusion-sensitized driven-equilibrium (iMDDSDE) preparation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Exploring neurodegenerative disorders using advanced magnetic resonance imaging of the glymphatic system.Frontiers in psychiatry · 2024Review
- Concurrent measurement of perfusion parameters related to small blood vessels and cerebrospinal fluid circulation in the human brain using dynamic dual-spin-echo perfusion MRI.NMR in biomedicine · 2023Article
- Prospective T1 mapping to assess gadolinium retention in brain after intrathecal gadobutrol.Neuroradiology · 2023Article
- Prospective Safety Study of Intrathecal Gadobutrol in Different Doses.AJNR. American journal of neuroradiology · 2023Article
- Conserved meningeal lymphatic drainage circuits in mice and humans.The Journal of experimental medicine · 2022Article
- Age-dependent cerebrospinal fluid-tissue water exchange detected by magnetization transfer indirect spin labeling MRI.Magnetic resonance in medicine · 2022Article
- Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes.Nature communications · 2022Article
- Intrathecal Contrast-Enhanced Magnetic Resonance Imaging of Cerebrospinal Fluid Dynamics and Glymphatic Enhancement in Idiopathic Normal Pressure Hydrocephalus.Frontiers in neurology · 2022Article
- Achieving brain clearance and preventing neurodegenerative diseases-A glymphatic perspective.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Off-label intrathecal use of gadobutrol: safety study and comparison of administration protocols.Neuroradiology · 2021Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe circulation of cerebrospinal fluid (CSF) is closely associated with many aspects of brain physiology. When gadolinium(Gd)-based contrast is administered intravenously, pre- and post-contrast MR signal changes can often be observed in the CSF at certain locations within the intra-cranial space, mainly due to the lack of a blood-brain barrier in the dural blood vessels. This study aims to develop and systemically optimize MRI sequences that can detect dynamic signal changes in the CSF after Gd administration with a sub-millimeter spatial resolution, a temporal resolution of <10 s, and whole brain coverage.
methodsBloch simulations were performed to determine optimal imaging parameters for maximum CSF contrast before and after Gd injection. Simulations were validated with phantom scans. An optimized turbo-spin-echo (TSE) sequence was performed on healthy volunteers on 3T and 7T.
resultsSimulation results agreed well with phantom scans. In human scans, dynamic signal changes after Gd injection in the CSF were detected at several locations where cerebral lymphatic vessels were identified in previous studies. The concentration of Gd in CSF in these regions was estimated to be approximately 0.2 mmol/L.
conclusionDynamic signal changes induced by the distribution of Gd in the CSF can be detected in healthy human subjects with an optimized TSE sequence. The proposed methodology does not rely on any particular theory on CSF circulation. We expect it to be useful for studies on CSF circulation and cerebral lymphatic vessels in the brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.