Evidence map›Paper›PMID 32621281›Full record

ArticleInfection2020

No SARS-CoV-2 detection in the German CAPNETZ cohort of community acquired pneumonia before COVID-19 peak in March 2020.

Marcus Panning, Julius Wiener, Kathrin Rothe, Jochen Schneider, Mathias W Pletz, Gernot Rohde, Jan Rupp, Martin Witzenrath, Christoph D Spinner, Members of the CAPNETZ study group

Open access · hybridAbstract readHistorical ArticleLetter
In one paragraph

Article in Infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Marcus PanningInstitute of Virology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Hermann-Herder-Str. 11, 79014, Freiburg, Germany. marcus.panning@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0003-3596-5964
Julius WienerInstitute of Virology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Hermann-Herder-Str. 11, 79014, Freiburg, Germany.
Kathrin RotheTechnical University Munich, School of Medicine, Institute for Medical Microbiology, Immunology and Hygiene, Munich, Germany.
Jochen SchneiderDepartment of Internal Medicine II, School of Medicine, Technical University Munich, University Hospital rechts der Isar, Munich, Germany.
Mathias W PletzInstitute of Infectious Diseases and Infection Control, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany.
Gernot RohdeDepartment of Respiratory Medicine, Medical Clinic I, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.
Jan RuppDepartment of Infectious Diseases and Microbiology, University Hospital Schleswig-Holstein, Lübeck, Germany.
Martin WitzenrathDepartment of Infectious Diseases and Pulmonary Medicine and Division of Pulmonary Inflammation, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Christoph D SpinnerDepartment of Internal Medicine II, School of Medicine, Technical University Munich, University Hospital rechts der Isar, Munich, Germany.
Members of the CAPNETZ study group
TUM Klinikum · DEUniversity of Freiburg · DEGoethe University Frankfurt · DEHumboldt-Universität zu Berlin · DEJena University Hospital · DEUniversity Hospital Schleswig-Holstein · DEInstitute of Medical Microbiology and Hygiene · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe first SARS-CoV-2 cases in Europe were reported in January 2020. Recently, concern arose on unrecognized infections before this date. For a better understanding of the pandemic, we retrospectively analyzed patient samples for SARS-CoV-2 from the prospective CAPNETZ study cohort.

methodsWe used nasopharyngeal swab samples from a cohort of well characterized patients with community acquired pneumonia of the CAPNETZ study group, recruited from different geographic regions across Germany, Austria, the Netherlands, and Switzerland between 02nd December 2019 and 28th April 2020. Multiplex real-time RT-PCR for a broad range of respiratory pathogens and SARS-CoV-2 real-time RT-PCR were performed on all samples.

resultsIn our cohort, respiratory pathogens other than SARS-CoV-2 were detected in 21.5% (42/195) of patients with rhinovirus as the most frequently detected pathogen. The detection rate increased to 29.7% (58/195) when SARS-CoV-2 was included. No SARS-CoV-2 positive sample was detected before end of March 2020.

conclusionsRespiratory viral pathogens accounted for a considerable number of positive results but no SARS-CoV-2 case was identified before the end of March 2020.

Indexed as

AdultAgedAged, 80 and overCohort StudiesCommunity-Acquired InfectionsCOVID-19FemaleGermanyHistory, 21st CenturyHumansMaleMiddle AgedMultiplex Polymerase Chain ReactionPneumoniaSARS-CoV-2Young AdultCommunity acquired pneumoniaEpidemiologyMultiplex RT-PCRRespiratory pathogensSARS-CoV-2

Identifiers

PMID32621281
PMCPMC7332473
OpenAlexW3038803804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.