Evidence map›Paper›PMID 32621255›Full record

ArticleJournal of natural medicines2020

Isolation and evaluation of trypanocidal activity of sesquiterpenoids, flavonoids, and lignans in Artemisia sieversiana collected in Mongolia.

Stipan Nurbek, Toshihiro Murata, Keisuke Suganuma, Yoshinobu Ishikawa, Buyanmandakh Buyankhishig, Takashi Kikuchi, Tseesuren Byambajav, Bekh-Ochir Davaapurev, Kenroh Sasaki, Javzan Batkhuu

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Molecules (Basel, Switzerland) · 2021
    Review
  4. Research Advances on Health Effects of EdibleFoods (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Stipan NurbekNational University of Mongolia, Ulaanbaatar, Mongolia.
Toshihiro MurataDepartment of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai, 981-8558, Japan. murata-t@tohoku-mpu.ac.jp.ORCID http://orcid.org/0000-0001-7778-3822
Keisuke SuganumaNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Yoshinobu IshikawaUniversity of Shizuoka, Shizuoka, Japan.
Buyanmandakh BuyankhishigDepartment of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai, 981-8558, Japan.
Takashi KikuchiRigaku Corporation, Tokyo, Japan.
Tseesuren ByambajavInstitute of Veterinary Medicine, Mongolian University of Life Sciences, Ulaanbaatar, Mongolia.
Bekh-Ochir DavaapurevNational University of Mongolia, Ulaanbaatar, Mongolia.
Kenroh SasakiDepartment of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai, 981-8558, Japan.
Javzan BatkhuuNational University of Mongolia, Ulaanbaatar, Mongolia.
National University of Mongolia · MNTohoku Medical and Pharmaceutical University · JPMongolian University of Life Sciences · MNObihiro University of Agriculture and Veterinary Medicine · JPRigaku (Japan) · JPUniversity of Shizuoka · JP

Funding

Consulting service project from the Ministry of Food, Agriculture and Light Industry of Mongolia 190812/04.294Cooperative Research Grant from the National Research Center for Protozoan Diseases 31-joint-5JSPS Kakenhi JP19K16397
6 · The paper itself

Abstract

Artemisia sieversiana is an annual herbaceous plant distributed throughout Central and East Eurasia and is regarded as an undesirable forage plant in Mongolia. It affects livestock, so information about its chemical composition is needed. We isolated three new sesquiterpenoids (1-3) and known compounds from A. sieversiana and investigated their activities. The absolute configuration of 1 was established using single-crystal X-ray diffraction crystallography, and its configuration differed from those of reported compounds with similar structures. Two additional new sesquiterpenoids (2 and 3) with similar structures were identified, and their configurations were determined. The trypanocidal activities of the isolated compounds (1-18) against Trypanosoma congolense and the pathogen responsible for fatal trypanosomosis in animals were estimated. Flavonoids and lignans were identified as active compounds with IC

Indexed as

ArtemisiaFlavonoidsLignansMolecular StructureMongoliaPlantsSesquiterpenesFlavonoidsLignansSesquiterpenesArtemisia sieversianaCompositaeLignanPolymethoxyflavonoidSesquiterpenoidTrypanosoma congolense

Identifiers

PMID32621255
OpenAlexW3039757544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.