Evidence map›Paper›PMID 32621176›Full record

ArticleCellular and molecular neurobiology2021

Regulation of PGE

Yunfei Xu, Ying Liu, Kexin Li, Shuying Miao, Caihong Lv, Chunjiang Wang, Jie Zhao

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Pooled it
  2. Article
  3. Review
  4. Impacts of Oxylipins on ischemic stroke: from pathophysiology to clinical phenotypes.Metabolomics : Official journal of the Metabolomic Society · 2025
    Review
  5. Article
  6. Article
  7. Polyphenolic metabolites inFrontiers in pharmacology · 2025
    Review
  8. Article
  9. Article
  10. Update on the pathological roles of prostaglandin ETranslational neurodegeneration · 2023
    Review
  11. The inducible prostaglandin E synthase (mPGES-1) in neuroinflammatory disorders.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Inducible Prostaglandin E Synthase as a Pharmacological Target for Ischemic Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yunfei Xu *Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.ORCID http://orcid.org/0000-0001-8017-9263
Ying Liu *Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China. liu1977ying@126.com.
Kexin LiDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.
Shuying MiaoDepartment of Pathology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, 210008, Jiangsu, China.
Caihong LvDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.
Chunjiang WangDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.
Jie ZhaoDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. steelzj@126.com.
Central South University · CNNanjing Drum Tower Hospital · CN

Funding

National Natural Science Foundation of China 30901555National Natural Science Foundation of China 30972870National Natural Science Foundation of China 81360080National Natural Science Foundation of China 81373147National Natural Science Foundation of China 81471897National Natural Science Foundation of China 81571880National Natural Science Foundation of China 81671895Natural Science Foundation of Hunan Province 2016JJ2157
6 · The paper itself

Abstract

Stroke is an acute central nervous system disease with high morbidity and mortality rate. Cerebral ischemia reperfusion (I/R) injury is easily induced during the development or treatment of stroke and subsequently leads to more serious brain damage. Prostaglandin E

Indexed as

AnimalsCells, CulturedCyclooxygenase 2CytokinesDinoprostoneMaleProstaglandin-E SynthasesRatsRats, Sprague-DawleyReperfusion InjuryUp-RegulationCyclooxygenase 2CytokinesDinoprostoneProstaglandin-E Synthases15-PGDHCerebral ischemia reperfusion injuryCOXEPInflammationPGESProstaglandin E2

Identifiers

PMID32621176
PMCPMC11448554
OpenAlexW3039473657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.