Evidence map›Paper›PMID 32621113›Full record

ArticleImmunologic research2020

Patients with radiation enteritis present regulatory T cell impairment associated with CTLA-4.

Xufeng Gong, Genhua Yu, Zongchang Song, Shuqi Huang, Yan Hou, Ning Wang, Wei Zhao, Jingjing Ouyang, Zhengzhou Gu, Haili Hu and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Immunologic research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Xufeng GongDepartment of Radiotherapy, Huzhou Zhebei Mingzhou Hospital, Huzhou, Zhejiang, China.
Genhua YuDepartment of Radiotherapy, Huzhou Zhebei Mingzhou Hospital, Huzhou, Zhejiang, China.
Zongchang SongDepartment of Oncology, Tianyou Hospital Affiliated to Tongji University, Shanghai, China.
Shuqi HuangDepartment of Neurology, Tianyou Hospital Affiliated to Tongji University, Shanghai, China.
Yan HouDepartment of Radiotherapy, Huzhou Zhebei Mingzhou Hospital, Huzhou, Zhejiang, China.
Ning WangDepartment of Radiotherapy, Huzhou Zhebei Mingzhou Hospital, Huzhou, Zhejiang, China.
Wei ZhaoDepartment of Radiotherapy, Huzhou Zhebei Mingzhou Hospital, Huzhou, Zhejiang, China.
Jingjing OuyangDepartment of Radiotherapy, Huzhou Zhebei Mingzhou Hospital, Huzhou, Zhejiang, China.
Zhengzhou GuDepartment of Radiotherapy, Huzhou Zhebei Mingzhou Hospital, Huzhou, Zhejiang, China.
Haili HuDepartment of Radiotherapy, Huzhou Zhebei Mingzhou Hospital, Huzhou, Zhejiang, China.
Lei FeiDepartment of Radiotherapy, Huzhou Zhebei Mingzhou Hospital, Huzhou, Zhejiang, China.
Aixia FuDepartment of Pediatrics, Huzhou Hospital of Traditional Chinese medicine, Huzhou, Zhejiang, China.
Jingping XiaMedical Department, Huzhou Zhebei Mingzhou Hospital, Huzhou, Zhejiang, China.
Yuehua DingOutpatient Department, Huzhou Maternity and Child Health Care Hospital, No.2 Dongjie Road, Huzhou, Zhejiang, China. jessica558866@sina.com.ORCID 0000-0002-6196-3068
Huzhou Central Hospital · CNTongji University · CNHuzhou University · CNHuzhou Women and Children's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation enteritis is one of the most common side effects of ionizing radiation in patients with pelvic cancers. Increasing amounts of evidence indicate that pro-inflammatory responses significantly contribute to the development of radiation enteritis. In this study, we investigated the association between T regulatory (Treg) cells and the risk of developing radiation enteritis in cervical cancer patients. The following observations were made. First, the frequencies of CD25

Indexed as

Case-Control StudiesCTLA-4 AntigenEnteritisFemaleFollow-Up StudiesHealthy VolunteersHumansLymphocyte ActivationRadiation InjuriesSeverity of Illness IndexT-Lymphocytes, RegulatoryUterine Cervical NeoplasmsCTLA-4 AntigenCTLA4 protein, humanCTLA-4Radiation enteritisTreg cell

Identifiers

PMID32621113
OpenAlexW3039101919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.