ReviewSkeletal radiology2021
Image-guided botulinum toxin injection in the lateral abdominal wall prior to abdominal wall reconstruction surgery: review of techniques and results.
Review in Skeletal radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Prehabilitation of complex ventral hernia patients with Botulinum: a systematic review of the quantifiable effects of Botulinum.Hernia : the journal of hernias and abdominal wall surgery · 2021Pooled it
- Ultrasound-guided botulinum toxin injections for abdominal spasticity and dyspnea in an ambulatory patient with an incomplete cervical spinal cord injury: a case report.Journal of medical case reports · 2026Article
- Ultrasound alone is sufficient: no added value of electromyography in botulinum toxin prehabilitation for complex ventral hernias?Hernia : the journal of hernias and abdominal wall surgery · 2026Observational
- Long-Term Outcomes of Preoperative Botulinum Toxin Use in Abdominal Wall Reconstruction: A Propensity-Matched Analysis of More Than 5000 Patients Over 5 Years.Aesthetic surgery journal. Open forum · 2026Article
- Early outcomes of contaminated midline incisional hernia repair with mesh suture.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Outcomes Following Implantation With Mesh Suture: A Registry of 1111 Patients.Plastic and reconstructive surgery. Global open · 2025Article
- Preoperative Image-guided Botulinum Toxin A Injection in Complex Abdominal Wall Hernia Repair.Interventional radiology (Higashimatsuyama-shi (Japan) · 2025Article
- Preoperative Botulinum Toxin A (BTA) injection in abdominal wall reconstruction for subxiphoid (M1) hernias.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Complex Abdominal Wall Hernias: Structured Use of Adjuvant Therapies.Journal of abdominal wall surgery : JAWS · 2025Article
- A Preoperative Algorithm for Loss of Domain Hernia Repair: Stratified Management Using the Tanaka Index in 50 Cases.Journal of abdominal wall surgery : JAWS · 2025Article
- Case Report: Combined Preperitoneal Enhanced-View Totally Extraperitoneal (PeTEP) Repair with Intraoperative Fascial Traction after Prehabilitation with Botulinum Toxin A in a Large Congenital Umbilical Hernia.Journal of abdominal wall surgery : JAWS · 2025Article
- Concurrent Panniculectomy With Abdominal Wall Reconstruction: A Propensity-scored Matched Study of Quality Improvement Outcomes.Plastic and reconstructive surgery. Global open · 2024Article
- Achieving fascial closure with preoperative botulinum toxin injections in abdominal wall reconstruction: outcomes from a high-volume center.Updates in surgery · 2024Article
- The effect of preoperative botulinum toxin a injection on traction force during hernia repair: a prospective, single-blind study, intra-patient comparison using contralateral side as a control.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Prevention of component separation in complex abdominal wall surgery by Botox prehabilitation: a propensity-matched study.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Botulinum Toxin A as an Adjunct for the Repair Giant Inguinal Hernias: Case Reports and a Review of the Literature.Journal of clinical medicine · 2024Review
- Volumetry after botulinum toxin A: the impact on abdominal wall compliance and endotracheal pressure.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Preoperative Botulinum Toxin-A Injections Prior to Abdominal Wall Reconstruction Can Lead to Cardiopulmonary Complications.Journal of abdominal wall surgery : JAWS · 2024Article
- A computed tomography study investigating the effects of botulinum toxin injections prior to complex abdominal wall reconstruction.Hernia : the journal of hernias and abdominal wall surgery · 2023Article
- State-of-the-art abdominal wall reconstruction and closure.Langenbeck's archives of surgery · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ventral hernias represent the most common complication after abdominal surgery. Loss of domain and/or large ventral hernias in patients are especially challenging for surgeons to manage, but preoperative image-guided botulinum toxin injection has emerged as an effective adjunct to abdominal wall surgery. Loss of domain is caused by chronic muscle retraction of the lateral abdominal wall and leads to an irreducible protrusion of abdominal viscera into the hernia sac. Botulinum toxin can be used in the oblique muscles as a chemical component relaxation technique to aid abdominal wall reconstruction. Intramuscular botulinum toxin injection causes functional denervation by blocking neurotransmitter acetylcholine release resulting in flaccid paralysis and elongation of lateral abdominal wall muscles, increasing the rate of fascial closure during abdominal wall reconstruction, and decreasing recurrence rates. In total, 200-300 units of onabotulinumtoxinA (Botox®) or 500 units of abobotulinumtoxinA (Dypsort®) in a 2:1 dilution with normal saline is most commonly used. Botulinum toxin can be injected with ultrasonographic, EMG, or CT guidance. Injection should be performed at least 2 weeks prior to abdominal wall reconstruction, for maximal effect during surgery. At minimum, botulinum toxin should be injected into the external and internal oblique muscles at three separate sites bilaterally for a total of six injections. Although botulinum toxin use for abdominal wall reconstruction is currently not indicated by the Food and Drug Administration, it is safe with only minor complications reported in literature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.