Evidence map›Paper›PMID 32620998›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2020

Genetically programmed changes in transcription of the novel progranulin regulator.

Maria Keller, Claudia Gebhardt, Sandra Huth, Dorit Schleinitz, Henrike Heyne, Markus Scholz, Michael Stumvoll, Yvonne Böttcher, Anke Tönjes, Peter Kovacs

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Maria Keller *Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, University Hospital Leipzig, University of Leipzig, 04103, Leipzig, Germany.
Claudia Gebhardt *Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, University Hospital Leipzig, University of Leipzig, 04103, Leipzig, Germany.
Sandra HuthInstitute of Biochemistry, Medical Faculty, University of Leipzig, 04103, Leipzig, Germany.
Dorit SchleinitzMedical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103, Leipzig, Germany.
Henrike HeyneInstitute of Human Genetics, University of Leipzig, 04103, Leipzig, Germany.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107, Leipzig, Germany.
Michael StumvollHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich, University Hospital Leipzig, University of Leipzig, 04103, Leipzig, Germany.
Yvonne BöttcherInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Anke TönjesMedical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103, Leipzig, Germany. Anke.Toenjes@medizin.uni-leipzig.de.
Peter KovacsMedical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103, Leipzig, Germany. Peter.Kovacs@medizin.uni-leipzig.de.ORCID http://orcid.org/0000-0002-0290-5423
University Hospital Leipzig · DELeipzig University · DEMalmö University · SEUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progranulin is a glycoprotein marking chronic inflammation in obesity and type 2 diabetes. Previous studies suggested PSRC1 (proline and serine rich coiled-coil 1) to be a target of genetic variants associated with serum progranulin levels. We aimed to identify potentially functional variants and characterize their role in regulation of PSRC1. Phylogenetic module complexity analysis (PMCA) prioritized four polymorphisms (rs12740374, rs629301, rs660240, rs7528419) altering transcription factor binding sites with an overall score for potential regulatory function of S

Indexed as

Gene Expression RegulationGenetic VariationTranscription, GeneticAdultAgedAllelesCell LineDNA MethylationEpigenesis, GeneticFemaleGenes, ReporterGenotypeHumansMaleMiddle AgedPhylogenyProgranulinsRNA, MessengerYY1 Transcription FactorDNA methylationEMSAProgranulinPSRC1

Identifiers

PMID32620998
PMCPMC7399677
OpenAlexW3038255565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.