ArticleJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2021
The effect of roller head pump on platelet deterioration during the simulated extracorporeal circulation.
Article in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Hemocompatibility of Mechanical Circulatory Support Devices: An Integrated Review of Platelet Function Assessment in In-Vitro Blood Experiments.Annals of biomedical engineering · 2026Pooled it
- Is Fibrin a Suitable Matrix for Small-Diameter Bioartificial Vascular Grafts? An In Vitro Short-Term Hemocompatibility Study.Journal of functional biomaterials · 2026Article
- Hemodynamic implications of direct sheath insertion through VA-ECMO arterial cannula: an In-Vitro model.Cardiovascular intervention and therapeutics · 2026Article
- Strategies to predict and decrease flow rate pulsation in a rotary peristaltic pump with novel tube design.Medical & biological engineering & computing · 2026Article
- A simple predictive marker of inflammation: systemic immune‑inflammation index.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2023Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Roller pumping results in hemolysis and adverse effects on coagulation, but there are few reports on the influence of roller heads on platelets. Here, we evaluate the interaction between roller pumping and platelet function using a simulated extracorporeal circuit incorporating a vinyl chloride tube and roller head pump with 30 min recirculation. Platelet aggregation, platelet count, microparticle, P-selectin, Phosphatidylserine (PS) exposure and Ricinus Communis Agglutinin 1 (RCA-1) were measured before, 5, 10, 20, and 30 min after the recirculation using 100 ml of fresh human blood that had obtained from healthy volunteers (n = 9). Platelet aggregation and platelet count gradually decreased but microparticles significantly increased after the recirculation (P < 0.05). P-selectin, PS exposure and RCA-1 were measured using flow cytometry. There were no significant differences in the P-selectin and PS exposure expression during recirculation. RCA-1, a platelet apoptosis markers, significantly increased 30 min after recirculation (P < 0.05). We thus conclude that roller pumping induced platelet apoptosis and caused decreases in platelet count and aggregation after the recirculation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.