ArticleScientific reports2020
Resting state functional connectivity of the pain matrix and default mode network in irritable bowel syndrome: a graph theoretical analysis.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Effects and Mechanisms of Acupuncture on Diarrhea-Predominant Irritable Bowel Syndrome: A Systematic Review.Frontiers in neuroscience · 2022Pooled it
- Assessment of gut-brain interactions: reframing DGBI symptoms from visceral hypersensitivity to computational interoceptive overfitting.Frontiers in physiology · 2026Article
- Disrupted prefrontal-sensorimotor functional connectivity mediates the association between depression and symptom severity in patients with irritable bowel syndrome.Frontiers in human neuroscience · 2026Article
- Transcriptional signatures of aberrant brain functional network topology in chronic low back pain with lumbar disc herniation.Frontiers in molecular neuroscience · 2026Article
- Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain.Neuron · 2023Article
- Gut Microbiome-Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders.ACS chemical neuroscience · 2023Review
- Neuroimaging in Breast Implant Illness: An fMRI Pilot Study.Aesthetic surgery journal · 2023Article
- Functional brain neuroimaging as a tool to study gastrointestinal manifestations in patients with Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome.World journal of gastroenterology · 2022Review
- Brain Network Topology and Structural-Functional Connectivity Coupling Mediate the Association Between Gut Microbiota and Cognition.Frontiers in neuroscience · 2022Article
- Global Research Trends in Irritable Bowel Syndrome: A Bibliometric and Visualized Study.Frontiers in medicine · 2022Article
- Altered Structural Covariance of Insula, Cerebellum and Prefrontal Cortex Is Associated with Somatic Symptom Levels in Irritable Bowel Syndrome (IBS).Brain sciences · 2021Article
- Article
- Functional Disruptions of the Brain in Low Back Pain: A Potential Imaging Biomarker of Functional Disability.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irritable bowel syndrome (IBS) is a functional disorder of brain-gut interactions. Differential brain responses to rectal distention between IBS and healthy controls (HCs) have been demonstrated, particularly in the pain matrix and the default mode network. This study aims to compare resting-state functional properties of these networks between IBS patients and HCs using graph analysis in two independent cohorts. We used a weighted graph analysis of the adjacency matrix based on partial correlations between time series in the different regions in each subject to determine subject specific graph measures. These graph measures were normalized by values obtained in equivalent random networks. We did not find any significant differences between IBS patients and controls in global normalized graph measures, hubs, or modularity structure of the pain matrix and the DMN in any of our two independent cohorts. Furthermore, we did not find consistent associations between these global network measures and IBS symptom severity or GI-specific anxiety but we found a significant difference in the relationship between measures of psychological distress (anxiety and/or depressive symptoms) and normalized characteristic path length. The responses of these networks to visceral stimulation rather than their organisation at rest may be primarily disturbed in IBS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.