ArticleScientific reports2020
Effects of Roundup and its main component, glyphosate, upon mammalian sperm function and survival.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 76 citations in OpenAlex.
- The role of hydration in the removal of glyphosate (GLY) and aminomethylphosphonic acid (AMPA) by nanofiltration membranes.Nature communications · 2026Article
- Dietary exposure to pesticides in poultry: From semen quality to embryonic mortality and tissue accumulation.Poultry science · 2026Article
- Coenzyme Q10 protects against glyphosate-based herbicide-induced testicular and sperm toxicity by modulating Nrf2/Keap1/HO-1 and TLR4/NF-κB pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Toxicological concerns regarding glyphosate, its formulations, and co-formulants as environmental pollutants: a review of published studies from 2010 to 2025.Archives of toxicology · 2025Review
- Cadmium and glyphosate jointly compromise sperm function, fertilization, and early development inFrontiers in toxicology · 2025Article
- Glyphosate: Hepatotoxicity, Nephrotoxicity, Hemotoxicity, Carcinogenicity, and Clinical Cases of Endocrine, Reproductive, Cardiovascular, and Pulmonary System Intoxication.ACS pharmacology & translational science · 2024Review
- Glyphosate Separating and Sensing for Precision Agriculture and Environmental Protection in the Era of Smart Materials.Environmental science & technology · 2023Review
- Acute exposure to organophosphorus pesticide metabolites compromises buffalo sperm function and impairs fertility.Scientific reports · 2023Article
- Bisphenol S Reduces Pig Spermatozoa Motility through Different Intracellular Pathways and Mechanisms than Its Analog Bisphenol A.International journal of molecular sciences · 2023Article
- Biological effects of sub-lethal doses of glyphosate and AMPA on cardiac myoblasts.Frontiers in physiology · 2023Article
- The adverse impact of herbicide Roundup Ultra Plus in human spermatozoa plasma membrane is caused by its surfactant.Scientific reports · 2022Article
- Rethinking the Intrinsic Sensitivity of Fungi to Glyphosate.Biotech (Basel (Switzerland)) · 2022Article
- The effects of low-toxic herbicide Roundup and glyphosate on mitochondria.EXCLI journal · 2022Review
- Contribution of insect gut microbiota and their associated enzymes in insect physiology and biodegradation of pesticides.Frontiers in microbiology · 2022Review
- Reproductive toxicity of roundup®-treated feed on broiler breeder roosters and the amelioration of these deleterious effects with inclusion of humic acids in feed.Veterinary and animal science · 2021Article
- Article
- Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development.International journal of molecular sciences · 2021Review
- Review
- Impact of Estrogens Present in Environment on Health and Welfare of Animals.Animals : an open access journal from MDPI · 2021Review
- Pesticides: formulants, distribution pathways and effects on human health - a review.Toxicology reports · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The wide use of glyphosate-based herbicides (GBHs) has become a matter of concern due to its potential harmful effects on human health, including men fertility. This study sought to investigate, using the pig as a model, the impact of pure glyphosate and its most known commercial formulation, Roundup, on sperm function and survival. With this purpose, fresh commercial semen doses were incubated with different concentrations (0-360 µg/mL) of glyphosate (GLY; exp. 1) or Roundup, at the equivalent GLY concentration (exp. 2), at 38 °C for 3 h. Glyphosate at 360 µg/mL significantly (P < 0.05) decreased sperm motility, viability, mitochondrial activity and acrosome integrity but had no detrimental effect at lower doses. On the other hand, Roundup did significantly (P < 0.05) reduce sperm motility at ≥ 5 µg/mL GLY-equivalent concentration; mitochondrial activity at ≥ 25 µg/mL GLY-equivalent concentration; and sperm viability and acrosome integrity at ≥ 100 µg/mL GLY-equivalent concentration as early as 1 h of incubation. In a similar fashion, GLY and Roundup did not inflict any detrimental effect on sperm DNA integrity. Taken together, these data indicate that, while both glyphosate and Roundup exert a negative impact on male gametes, Roundup is more toxic than its main component, glyphosate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.