Trial reportScientific reports2020
Effect of occlusal splint on oxidative stress markers and psychological aspects of chronic temporomandibular pain: a randomized controlled trial.
Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04694274 (Genetic Polymorphisms and Their Association With Temporomandibular Disorders), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Polymorphisms and Their Association With Temporomandibular Disorders
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The Role of Biomarkers in Temporomandibular Disorders: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Occlusal interventions for managing temporomandibular disorders.The Cochrane database of systematic reviews · 2024Pooled it
- Evaluating amitriptyline's role in chronic TMD management: a placebo-controlled trial.BMC oral health · 2025Trial
- Effectiveness of Ultrasound Therapy, TheraBite Device, Masticatory Muscle Exercises, and Stabilization Splint for the Treatment of Masticatory Myofascial Pain: A Randomized Controlled Trial.Clinical and experimental dental research · 2024Trial
- Diagnosis-based pathways for conservative and minimally invasive management of temporomandibular disorders: a scoping review.Journal of oral & facial pain and headache · 2026Article
- Centric stabilization occlusal splints vs. other conservative therapies in the management of temporomandibular disorders: a systematic review and meta-analysis.The Saudi dental journal · 2025Review
- Review
- Temporomandibular Internal Derangements Denote Activity of Axial Spondyloarthritis.Acta stomatologica Croatica · 2025Article
- Correlations of oral behaviors, pain, and psychological distress among patients with temporomandibular disorders: clinical investigation of axial II evaluation.Frontiers in public health · 2025Observational
- Opiorphin: an endogenous human peptide with intriguing application in diverse range of pathologies.Inflammopharmacology · 2024Review
- Genetic Influences of Proinflammatory Cytokines on Pain Severity in Patients with Temporomandibular Disorders.International journal of molecular sciences · 2024Article
- Analysis of the Use of Sample Size and Effect Size Calculations in a Temporomandibular Disorders Randomised Controlled Trial-Short Narrative Review.Journal of personalized medicine · 2024Review
- Biocompatibility of 3D-printed vs. thermoformed and heat-cured intraoral appliances.Frontiers in bioengineering and biotechnology · 2024Article
- Oxidative imbalance as a co-player in jaw functional limitations and biopsychosocial profile in patients with temporomandibular disorder-myofascial pain with referral.Frontiers in neurology · 2024Article
- Association of Oxidative-Stress-Related Gene Polymorphisms with Pain-Related Temporomandibular Disorders and Oral Behavioural Habits.Antioxidants (Basel, Switzerland) · 2023Article
- Psychological Outcomes on Anxiety and Depression after Interventions for Temporomandibular Disorders: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2023Review
- Salivary biomarkers as key to monitor personalized oral healthcare and precision dentistry: A scoping review.Frontiers in oral health · 2022Article
- Profiling of Patients with Temporomandibular Disorders: Experience of One Tertiary Care Center.Acta stomatologica Croatica · 2021Article
- Biomarkers in orofacial pain conditions: A narrative review.Journal of oral biology and craniofacial researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temporomandibular disorders (TMD), when progress to a chronic state, might contribute to psychosocial or psychological distress. This study aimed to evaluate the effect of stabilization splint (SS) therapy on pain, pain-related disability and psychological traits of chronic TMD patients, as well as to assess selected oxidative stress (OS) biomarkers during 6-month treatment and associate them with the symptoms of anxiety and depression. Thirty-four participants were randomly assigned into two treatment groups [SS and placebo splint (PS)]. Primary outcomes were pain intensity and pain-related disability while secondary outcomes included depressive and anxiety symptoms. The influence of the treatment type was analyzed with regards to the levels of OS biomarkers in saliva. Participants treated with SS demonstrated significantly greater improvement in pain-related disability (Pain-free mouth opening: p = 0.018, η
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.