ArticleNature communications2020
NCLX prevents cell death during adrenergic activation of the brown adipose tissue.
Open access · goldAbstract readVideo-Audio Media
In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Mitochondrial-endoplasmic reticulum interactions in lung diseases.Cell death & disease · 2026Review
- Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets.The EMBO journal · 2026Article
- Metal-dependent regulated cell death: Molecular architecture and translational frontiers.iMeta · 2026Review
- Chronic cold exposure induces plasticity of mitochondrial calcium uptake in beige and brown fat of UCP1-deficient mice.bioRxiv : the preprint server for biology · 2026Article
- Tmbim5 and Slc8b1 cooperate in tissue-specific mitochondrial calcium regulation in zebrafish.Communications biology · 2026Article
- Article
- TMEM65 functions as the mitochondrial NaNature cell biology · 2025Article
- NCLX controls hepatic mitochondrial CaMolecular metabolism · 2024Article
- Dysfunctional mitochondria elicit bioenergetic decline in the aged heart.The journal of cardiovascular aging · 2024Article
- Dihydroartemisinin inhibits liver cancer cell migration and invasion by reducing ATP synthase production through CaMKK2/NCLX.Oncology letters · 2023Article
- Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance.Journal of neurochemistry · 2023Article
- Beyond the matrix: structural and physiological advancements in mitochondrial calcium signaling.Biochemical Society transactions · 2023Review
- The Therapeutic Strategies Targeting Mitochondrial Metabolism in Cardiovascular Disease.Pharmaceutics · 2022Review
- Essential role of the mitochondrial NaCell reports · 2022Article
- Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice.Nature metabolism · 2022Article
- Mitochondrial signal transduction.Cell metabolism · 2022Review
- Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer.Cellular and molecular life sciences : CMLS · 2022Article
- Mitochondrial calcium exchange in physiology and disease.Physiological reviews · 2022Review
- Lon upregulation contributes to cisplatin resistance by triggering NCLX-mediated mitochondrial CaCell death & disease · 2022Article
- Physiological and Pathophysiological Roles of Mitochondrial NaBiomolecules · 2021Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Essam A AssaliDivision of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0002-7788-7047
Anthony E JonesDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0003-2058-6021
Michaela VeliovaDivision of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Rebeca Acín-PérezDivision of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Mahmoud TahaDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84105, Israel.
Nathanael MillerDivision of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Michaël ShumDivision of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Marcus F OliveiraInstitute of Medical Biochemistry Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Guy LasDepartment of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84103, Israel.
Marc LiesaDivision of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0002-5909-8570
Israel SeklerDepartment of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84105, Israel. sekler@bgu.ac.il.
Orian S ShirihaiDivision of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA. Oshirihai@mednet.ucla.edu.ORCID http://orcid.org/0000-0001-8466-3431
University of California, Los Angeles · USBen-Gurion University of the Negev · ILUniversidade Federal do Rio de Janeiro · BR
Funding
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MMETABOLIC SIGNAL TRANSDUCTION IN ADIPOCYTESR01DK056690 · NIDDK · BOSTON MEDICAL CENTER · PI CORKEY, BARBARA E., SHIRIHAI, ORIAN S · 2001 to 2015
$6.3MMETABOLIC REGULATION OF INSULIN SECRETIONR01DK035914 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI CORKEY, BARBARA E., SHIRIHAI, ORIAN S · 1986 to 2013
$5.3MMitochondrial dynamics in beta cell function and dysfunctionR01DK074778 · NIDDK · TUFTS UNIVERSITY BOSTON · PI CORKEY, BARBARA E., SHIRIHAI, ORIAN S · 2007 to 2015
$3.5MMitochondrial regulation of energy efficiencyR01DK099618 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CORKEY, BARBARA E., SHIRIHAI, ORIAN S · 2014 to 2018
$1.8MNIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK035914NIDDK NIH HHS R01 DK056690NIDDK NIH HHS R01 DK074778NIDDK NIH HHS R01 DK099618
Abstract
A sharp increase in mitochondrial Ca
Indexed as
Adipocytes, BrownAdipose Tissue, BrownAdrenergic AgentsAnimalsApoptosisCalciumCells, CulturedCold TemperatureCyclosporineEnergy MetabolismFemaleIntravital MicroscopyMaleMiceMice, KnockoutMicroscopy, FluorescenceAdrenergic AgentsCalciumCyclosporine(melle-4)cyclosporinMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreNorepinephrineSlc8b1protein, mouseSodium-Calcium Exchanger
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.