ArticleNature communications2020
Upgrading ketone synthesis direct from carboxylic acids and organohalides.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
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Who cites it
23 citing papers in PubMed, 120 citations in OpenAlex.
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- A universal atomically dispersed cobalt catalyst for alkylation of ketones alcohols and lignin-derived compounds.Nature communications · 2026Article
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- Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis.Chemical reviews · 2024Review
- Propane wet reforming over PtSn nanoparticles on γ-AlNature communications · 2024Article
- Stereoselective benzylic C(spChemical science · 2024Article
- Unimolecular Fragment Coupling: A New Bond-Forming Methodology via the Deletion of Atom(s).JACS Au · 2024Review
- A π-conjugated covalent organic framework enables interlocked nickel/photoredox catalysis for light-harvesting cross-coupling reactions.Chemical science · 2023Article
- Rapid Synthesis of β-Chiral Sulfones by Ni-Organophotocatalyzed Enantioselective Sulfonylalkenylation of Alkenes.JACS Au · 2023Article
- α-Amino Radical Halogen Atom Transfer Agents for Metallaphotoredox-Catalyzed Cross-Electrophile Couplings of Distinct Organic Halides.ChemSusChem · 2022Article
- Highly congested spiro-compounds via photoredox-mediated dearomative annulation cascade.Communications chemistry · 2022Article
- Highly selective single and multiple deuteration of unactivated C(spNature communications · 2022Article
- Carbene and photocatalyst-catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles to form ketones.Nature communications · 2022Article
- Decarboxylative tandem C-N coupling with nitroarenes via SNature communications · 2022Article
- Highly selective synthesis of all-carbon tetrasubstituted alkenes by deoxygenative alkenylation of carboxylic acids.Nature communications · 2022Article
- Nickel-Mediated Photoreductive Cross Coupling of Carboxylic Acid Derivatives for Ketone Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Selective deoxygenative alkylation of alcohols via photocatalytic domino radical fragmentations.Nature communications · 2021Article
- Light-Driven Carbene Catalysis for the Synthesis of Aliphatic and α-Amino Ketones.Angewandte Chemie (International ed. in English) · 2021Article
- Site-specific Umpolung amidation of carboxylic acids via triplet synergistic catalysis.Nature communications · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The ketone functional group has a unique reactivity in organic chemistry and is associated with a number of useful reactions. Catalytic methods for ketone synthesis are continually being developed. Here, we report a photoredox, nickel and phosphoranyl radical synergistic cross-electrophile coupling of commercially available chemicals, aromatic acids and aryl/alkyl bromides. This allows for concise synthesis of highly functionalized ketones directly, without the preparation of activated carbonyl intermediates or organometallic compounds, and thus complements the conventional Weinreb ketone synthesis. Use of the appropriate photocatalyst, ligand amount and solvents can match the reaction rate required by any simple catalytic cycle. The practicality and synthetic robustness of the reaction are illustrated by the facile synthesis of complex ketones from readily available feedstock chemicals.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.