ArticleAging2020
Aging affects sex- and organ-specific trace element profiles in mice.
Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Hepatic methanethiol oxidase (MTO) activity of mice requires adequate dietary supply of copper.Redox biology · 2026Article
- Host immunosenescence compromisesAging · 2026Article
- Oxidative stress indicators mediated the association of dietary copper intake with low muscle mass: a cross-sectional study.NPJ science of food · 2025Article
- Distinct Clusters of Testosterone Levels, Symptoms, and Serum Trace Elements in Young Men: A Cross-Sectional Analysis.Nutrients · 2025Article
- Activity-based sensing reveals elevated labile copper promotes liver aging via hepatic ALDH1A1 depletion.Nature communications · 2025Article
- Liver iron stores and effectors of ferroptosis are dependent on age and sex.Experimental physiology · 2024Article
- Subzero project: comparing trace element profiles of enriched mitochondria fractions from frozen and fresh liver tissue.Analytical and bioanalytical chemistry · 2024Article
- Postprandial Micronutrient Variability and Bioavailability: An Interventional Meal Study in Young vs. Old Participants.Nutrients · 2024Article
- Long-term suboptimal dietary trace element supply does not affect trace element homeostasis in murine cerebellum.Metallomics : integrated biometal science · 2024Article
- Sex- and age-related differences in the inflammatory properties of cardiac fibroblasts: impact on the cardiosplenic axis and cardiac fibrosis.Frontiers in cardiovascular medicine · 2023Article
- Association between serum manganese and serum klotho in a 40-80-year-old American population from NHANES 2011-2016.Frontiers in aging · 2023Article
- Association between trace element concentrations in cancerous and non-cancerous tissues with the risk of gastrointestinal cancers in Eastern Iran.Environmental science and pollution research international · 2021Article
- Course and Survival of COVID-19 Patients with Comorbidities in Relation to the Trace Element Status at Hospital Admission.Nutrients · 2021Observational
- Evaluation of zinc and copper levels in vaginal tissues and whole blood: correlation with age.BMC women's health · 2021Article
- Article
- Copper interferes with selenoprotein synthesis and activity.Redox biology · 2020Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A decline of immune responses and dynamic modulation of the redox status are observed during aging and are influenced by trace elements such as copper, iodine, iron, manganese, selenium, and zinc. So far, analytical studies have focused mainly on single trace elements. Therefore, we aimed to characterize age-specific profiles of several trace elements simultaneously in serum and organs of adult and old mice. This allows for correlating multiple trace element levels and to identify potential patterns of age-dependent alterations. In serum, copper and iodine concentrations were increased and zinc concentration was decreased in old as compared to adult mice. In parallel, decreased copper and elevated iron concentrations were observed in liver. The age-related reduction of hepatic copper levels was associated with reduced expression of copper transporters, whereas the increased hepatic iron concentrations correlated positively with proinflammatory mediators and Nrf2-induced ferritin H levels. Interestingly, the age-dependent inverse regulation of copper and iron was unique for the liver and not observed in any other organ. The physiological importance of alterations in the iron/copper ratio for liver function and the aging process needs to be addressed in further studies.
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Registered trials
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