Evidence map›Paper›PMID 32620690›Full record

ArticleThe Journal of biological chemistry2020

Age matters: Grading granule secretion in beta cells.

Eleni Georgiadou, Guy A Rutter

Abstract readComment
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Eleni GeorgiadouSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Department of Metabolism, Reproduction, and Digestion, Imperial College London, London, United Kingdom.
Guy A RutterSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Department of Metabolism, Reproduction, and Digestion, Imperial College London, London, United Kingdom; Lee Kong Chian School of Medicine, Nan Yang Technological University, Singapore. Electronic address: g.rutter@imperial.ac.uk.

Funding

Medical Research Council MR/K001981/1Medical Research Council MR/K023667/1Medical Research Council MR/L02036X/1Medical Research Council MR/M012646/1Medical Research Council MR/N020472/1Medical Research Council MR/R010676/1Medical Research Council MR/R022259/1
6 · The paper itself

Abstract

Insulin is stored in secretory granules to facilitate rapid release in response to rising glucose levels, but the mechanisms by which these granules are identified and prioritized for secretion remains unclear. Using a fluorescent timer and flow cytometry-assisted organelle sorting, Yau

Indexed as

InsulinInsulin-Secreting CellsBodily SecretionsCytoplasmic GranulesInsulin SecretionSecretory VesiclesInsulin

Identifiers

PMID32620690
PMCPMC7335800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.