ArticleThe Journal of biological chemistry2020
Phosphorylation on Ser-359 of the α2 subunit in GABA type A receptors down-regulates their density at inhibitory synapses.
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Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Is the Activation of the Postsynaptic Ligand Gated Glycine- or GABABiomedicines · 2025Review
- Dexmedetomidine Reduces Presynaptic γ-Aminobutyric Acid Release and Prolongs Postsynaptic Responses in Layer 5 Pyramidal Neurons in the Primary Somatosensory Cortex ofInternational journal of molecular sciences · 2025Article
- The role of protein phosphorylation modifications mediated by iron metabolism regulatory networks in the pathogenesis of Alzheimer's disease.Frontiers in aging neuroscience · 2025Review
- Neurobeachin regulates receptor downscaling at GABAergic inhibitory synapses in a protein kinase A-dependent manner.Communications biology · 2024Article
- The PDE4 inhibitor apremilast modulates ethanol responses in Gabrb1-S409A knock-in mice via PKA-dependent and independent mechanisms.Neuropharmacology · 2024Article
- The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal CliScience · 2024Article
- Apremilast-induced increases in acute ethanol intoxication and decreases in ethanol drinking in mice involve PKA phosphorylation of GABANeuropharmacology · 2022Article
- GABAergic circuits of the basolateral amygdala and generation of anxiety after traumatic brain injury.Amino acids · 2022Review
- Regulation of Inhibitory Signaling at the Receptor and Cellular Level; Advances in Our Understanding of GABAergic Neurotransmission and the Mechanisms by Which It Is Disrupted in Epilepsy.Frontiers in synaptic neuroscience · 2022Review
- Regulation of GABAMembranes · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Yasuko NakamuraSchool of Biochemistry, Centre for Synaptic Plasticity, University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-0660-4126
Danielle H MorrowDepartment of Neuroscience, Tufts University, School of Medicine, Boston, Massachusetts, USA.
Anna J NathansonDepartment of Neuroscience, Tufts University, School of Medicine, Boston, Massachusetts, USA.
Jeremy M HenleySchool of Biochemistry, Centre for Synaptic Plasticity, University of Bristol, Bristol, United Kingdom.ORCID 0000-0003-3589-8335
Kevin A WilkinsonSchool of Biochemistry, Centre for Synaptic Plasticity, University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-8115-8592
Stephen J MossDepartment of Neuroscience, Tufts University, School of Medicine, Boston, Massachusetts, USA Stephen.Moss@Tufts.edu.
Tufts University · USUniversity of Bristol · GB
Funding
Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI Marina R Picciotto · 2004 to 2026
$37.1MThe Synthesis of GABA in Epileptic BrainP01NS054900 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI COULTER, DOUGLAS A · 2007 to 2011
$6.4MMechanisms that determine Glutamine synthetase activity in the brainR01NS081986 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2012 to 2022
$3.7MStudies on the structure of gamma-aminobutyric acid type A receptor subtypesR01MH118263 · NIMH · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2019 to 2023
$2.4MModulation of KCC2 activity and the postnatal development of synaptic inhibitionR01NS101888 · NINDS · TUFTS UNIVERSITY BOSTON · PI DEEB, TAREK ZIAD, MOSS, STEPHEN J · 2017 to 2021
$2.3MDissecting Mechanisms of GABAB-GIRK Plasticity with PsychostimulantsR01DA037170 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MOSS, STEPHEN J, SLESINGER, PAUL A · 2014 to 2018
$2.1MNovel actions of neurosteroids on GABA (A) receptor traffickingR01MH097446 · NIMH · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2013 to 2017
$2.1MNovel actions of neurosteroids on GABA (A) receptor traffickingR01NS108378 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2018 to 2022
$2.0MDeficits in KCC2 activity and the pathophysiology of Status EpilepticusR01NS087662 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2014 to 2018
$2.0MMechanisms that determine the activity of glutamine synthetase in the brainR21NS103865 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2018 to 2019
$454kDetermining the effects of human KCC2 mutations on neuronal excitabilityR21NS111338 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW · 2019 to 2020
$454kBiotechnology and Biological Sciences Research Council BB/K014358/1Medical Research Council MR/L003791/1NIDA NIH HHS P30 DA018343NIMH NIH HHS R01 MH118263NINDS NIH HHS P01 NS054900NINDS NIH HHS R01 NS081986NINDS NIH HHS R01 NS087662NINDS NIH HHS R01 NS101888NINDS NIH HHS R01 NS108378NINDS NIH HHS R21 NS103865NINDS NIH HHS R21 NS111338
Abstract
GABA type A receptors (GABA
Indexed as
Down-RegulationInhibitory Postsynaptic PotentialsAmino Acid SubstitutionAnimalsCyclic AMP-Dependent Protein KinasesMembrane ProteinsMiceMice, TransgenicMutation, MissensePhosphorylationProtein Phosphatase 2RatsRats, WistarReceptors, GABA-ARho Guanine Nucleotide Exchange FactorsSynapsesArhgef9 protein, mouseArhgef9 protein, ratCyclic AMP-Dependent Protein KinasesGabra2 protein, mouseGabra2 protein, ratgephyrinMembrane ProteinsProtein Phosphatase 2Receptors, GABA-ARho Guanine Nucleotide Exchange Factorsaxon initial segmentcollybistinGABAAR alpha 2 subunitGABA receptorGABRA2gephyrinmass spectrometry (MS)protein kinase A (PKA)protein phosphataseprotein phosphorylationsynapsesynaptic inhibition
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.