Evidence map›Paper›PMID 32620240›Full record

ReviewProgress in molecular biology and translational science2020

Autophagy in chronic lung disease.

Alexandra C Racanelli, Augustine M K Choi, Mary E Choi

Open access · greenAbstract readReview
In one paragraph

Review in Progress in molecular biology and translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Autophagy in asthma and chronic obstructive pulmonary disease.Clinical science (London, England : 1979) · 2022
    Article
  16. Oxidative Stress in Chronic Obstructive Pulmonary Disease.Antioxidants (Basel, Switzerland) · 2022
    Review
  17. Article
  18. Review
  19. Article
  20. Regulation of autophagy by miRNAs in human diseases.The Nucleus : an international journal of cytology and allied topics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alexandra C RacanelliDivision of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, United States; NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, United States.
Augustine M K ChoiDivision of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, United States; NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, United States.
Mary E ChoiNewYork-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, United States; Division of Nephrology and Hypertension, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, United States. Electronic address: mechoi@med.cornell.edu.
Cornell University · USNewYork–Presbyterian Hospital · US

Funding

The Role of HEME Oxygenase in Hyperoxic Lung InjuryR01HL055330 · NHLBI · YALE UNIVERSITY · PI CHOI, AUGUSTINE M, CHOI, MARY E · 1998 to 2021
$6.6M
HEME OXYGENASE 1--LUNG VASCULAR CELL HYPOXIC RESPONSER01HL060234 · NHLBI · YALE UNIVERSITY · PI CHOI, AUGUSTINE M, CHOI, MARY E · 1999 to 2017
$5.8M
Multidisciplinary Approach Training in Respiratory ResearchT32HL134629 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Robert J Kaner, Heather Winona Stout Delgado · 2018 to 2026
$5.2M
Metabolic dysfunction regulates mitophagy-dependent necroptosis in COPDR01HL132198 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, AUGUSTINE M, CHOI, MARY E · 2017 to 2020
$2.2M
Novel role of RIPK3-dependent necroptosis pathway in lung and kidney fibrosisR01HL133801 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, AUGUSTINE M, CHOI, MARY E · 2017 to 2020
$2.1M
NHLBI NIH HHS R01 HL055330NHLBI NIH HHS R01 HL060234NHLBI NIH HHS R01 HL132198NHLBI NIH HHS R01 HL133801NHLBI NIH HHS T32 HL134629
6 · The paper itself

Abstract

The development of chronic lung disease occurs as a consequence of multiple cellular events that involve an initial insult which often leads to the development of chronic inflammation, and the dysregulation of cellular proliferation and cell death mechanisms. Multiple cell types in the lung are key to the respiratory and protective/barrier functions necessary to manage the chronic exposures to environmental, mechanical, and oxidative stressors. Autophagy is essential to lung development and homeostasis, as well as the prevention and development of disease. The cellular process involves the collection and removal of unwanted organelles and proteins through lysosomal degradation. In recent years, investigations have addressed the roles of autophagy and selective autophagy in numerous chronic lung diseases. Here, we highlight recent advances on the role of autophagy in the pathogenesis of asthma, chronic obstructive pulmonary disease and emphysema, pulmonary arterial hypertension, and idiopathic pulmonary fibrosis.

Indexed as

AutophagyAnimalsAutophagosomesCigarette SmokingDisease Models, AnimalHomeostasisHumansInflammationLungLung DiseasesLysosomesMiceMice, KnockoutOrganellesStress, PhysiologicalTOR Serine-Threonine KinasesMTOR protein, humanTOR Serine-Threonine KinasesAsthmaAutophagyCOPDEmphysemaIdiopathic pulmonary fibrosisPulmonary hypertension

Identifiers

PMID32620240
PMCPMC8608369
OpenAlexW3011441212

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.