ArticleBMC infectious diseases2020
Vascular function and cardiovascular risk in a HIV infected and HIV free cohort of African ancestry: baseline profile, rationale and methods of the longitudinal EndoAfrica-NWU study.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 21 citations in OpenAlex.
- Estimated pulse wave velocity as an integrated hemodynamic risk indicator in obese women with gestational hypertension: A cross-sectional study.Physiological reports · 2026Article
- HIV and ART status at baseline are associated longitudinally with increased pulse wave velocity: findings from the Ndlovu Cohort Study.AIDS (London, England) · 2026Article
- Development and validation of a predictive model for metabolic syndrome in a large cohort of people living with HIV.Virology journal · 2024Article
- Noncommunicable Disease Conditions and HIV in Rural and Urban South Africa: 2005-2015.Ethnicity & disease · 2023Article
- Vascular dysfunction and body mass index in African adults with HIV.BMC cardiovascular disorders · 2023Article
- Cardiovascular Profile of South African Adults with Low-Level Viremia during Antiretroviral Therapy.Journal of clinical medicine · 2022Article
- Age-related differences in the vascular function and structure of South Africans living with HIV.Southern African journal of HIV medicine · 2022Review
- A Pilot Study: Hypertension, Endothelial Dysfunction and Retinal Microvasculature in Rheumatic Autoimmune Diseases.Journal of clinical medicine · 2021Article
- Assessment of the impact of HIV infection and anti-retroviral treatment on the cardiometabolic health of pregnant mothers and their offspring (ARTMOMSBABES).BMC cardiovascular disorders · 2021Article
- Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.PloS one · 2021Article
- Immune activation and arterial stiffness in lean adults with HIV on antiretroviral therapy.Southern African journal of HIV medicine · 2021Article
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Authors and funding
14 authors at 5 institutions in 4 countries.
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Abstract
backgroundPeople living with the Human Immunodeficiency Virus (PLHIV) have an increased susceptibility to develop non-communicable diseases such as cardiovascular disease (CVD). Infection with HIV contributes to the development of CVD independent of traditional risk factors, with endothelial dysfunction being the central physiological mechanism. While HIV-related mortality is declining due to antiretroviral treatment (ART), the number of deaths due to CVD is rising in South Africa - the country with the highest number of PLHIV and the world's largest ART programme. The EndoAfrica study was developed to determine whether HIV infection and ART are associated with cardiovascular risk markers and changes in vascular structure and function over 18 months in adults from different provinces of South Africa. This paper describes the rationale, methodology and baseline cohort profile of the EndoAfrica study conducted in the North West Province, South Africa.
methodsIn this case-control study, conducted between August 2017 and June 2018, 382 volunteers of African descent (276 women; 106 men), comprising of 278 HIV infected and 104 HIV free individuals were included. We measured health behaviours, a detailed cardiovascular profile, and performed biomarker analyses. We compared baseline characteristics, blood pressure, vascular function and biochemical markers between those infected and HIV free.
resultsAt baseline, the HIV infected participants were older (43 vs 39 years), less were employed (21% vs 40%), less had a tertiary education (7% vs 16%) and their body mass index was lower (26 vs 29 kg/m
conclusionDespite PLHIV being older, preliminary cross-sectional analysis suggests that PLHIV being treated with ART do not have poorer endothelial or vascular function compared to the HIV free participants. More detailed analyses on the baseline and follow-up data will provide further clarity regarding the cardiovascular profile of South Africans living with HIV.
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