Evidence map›Paper›PMID 32620009›Full record

ReviewInternational immunology2020

The relationship between CD4+ follicular helper T cells and CD8+ resident memory T cells: sisters or distant cousins?

Changwei Peng, Stephen C Jameson

Abstract readReview
In one paragraph

Review in International immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Zfp281 and Zfp148 control CD4Science immunology · 2023
    Article
  4. Transcriptional programming of CD4Science immunology · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Changwei PengCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Stephen C JamesonCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.

Funding

T Cell HomeostasisR01AI038903 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI STEPHEN C JAMESON · 2001 to 2026
$5.9M
T cell homeostasisR37AI038903 · NIAID · UNIVERSITY OF MINNESOTA · PI JAMESON, STEPHEN C · 2006 to 2015
$3.6M
MECHANISM AND ROLE OF T CELL RECEPTOR ANTAGONISMR29AI038903 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMESON, STEPHEN C · 1996 to 2000
$111k
NIAID NIH HHS R01 AI038903NIAID NIH HHS R29 AI038903NIAID NIH HHS R37 AI038903
6 · The paper itself

Abstract

Independent studies over the last decade have characterized the properties of non-circulating CD8+ 'resident' memory T cells (TRM), which offer barrier protective immunity in non-lymphoid tissues and CD4+ follicular helper T cells (TFH), which mediate B-cell help in lymphoid sites. Despite their very different biological roles in the immune system, intriguing parallels have been noted between the trafficking properties and differentiation cues of these populations, parallels which have only sharpened with recent findings. In this review, we explore the features that underlie these similarities and discuss whether these indicate meaningful homologies in the development of CD8+ TRM and CD4+ TFH or reflect resemblances which are only 'skin-deep'.

Indexed as

AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHumansICOSKLF2P2RX7S1PR1

Identifiers

PMID32620009
PMCPMC7478156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.