Evidence map›Paper›PMID 32619898›Full record

ArticleJournal of inorganic biochemistry2020

A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity.

Edinilton Muniz Carvalho, Lisa A Ridnour, Florêncio Sousa Gouveia Júnior, Pedro Henrique Bezerra Cabral, Nilberto Robson Falcão do Nascimento, David A Wink, Douglas W Franco, Mayara Jane Campos de Medeiros, Daniel de Lima Pontes, Elisane Longhinotti and 5 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Edinilton Muniz CarvalhoDepartamento de Química Orgânica e Inorgânica, Grupo de Bioinorgânica, Universidade Federal do Ceará-UFC, P.O Box 6021, Fortaleza, CE CEP 60440-900, Brazil; CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, BP 44099, F-31077 Toulouse, Cedex 4, France; Université de Toulouse, UPS, INPT, F-31077 Toulouse, Cedex 4, France.
Lisa A RidnourNational Cancer Institute, Cancer and Inflammation Program, Frederick, MD 21702, United States.
Florêncio Sousa Gouveia JúniorDepartamento de Química Orgânica e Inorgânica, Grupo de Bioinorgânica, Universidade Federal do Ceará-UFC, P.O Box 6021, Fortaleza, CE CEP 60440-900, Brazil.
Pedro Henrique Bezerra CabralInstituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará-UECE, Paranjana Av, 1700, Fortaleza, Ceará 60740-00, Brazil.
Nilberto Robson Falcão do NascimentoInstituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará-UECE, Paranjana Av, 1700, Fortaleza, Ceará 60740-00, Brazil.
David A WinkNational Cancer Institute, Cancer and Inflammation Program, Frederick, MD 21702, United States.
Douglas W FrancoInstituto de Química de São Carlos, Universidade de São Paulo-USP, P.O. Box 780, São Carlos, SP CEP 13566-590, Brazil.
Mayara Jane Campos de MedeirosLaboratório de Química de Coordenação e Polímeros (LQCPol), Instituto de Química, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59078-970, Brazil.
Daniel de Lima PontesLaboratório de Química de Coordenação e Polímeros (LQCPol), Instituto de Química, Universidade Federal do Rio Grande do Norte (UFRN), Natal CEP 59078-970, Brazil.
Elisane LonghinottiDepartamento de Química Analítica e Físico-Química, Universidade Federal do Ceará-UFC, P.O Box 6021, Fortaleza, CE CEP 60440-900, Brazil.
Tércio de Freitas PauloDepartamento de Química Orgânica e Inorgânica, Grupo de Bioinorgânica, Universidade Federal do Ceará-UFC, P.O Box 6021, Fortaleza, CE CEP 60440-900, Brazil.
Vania Bernardes-GénissonCNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, BP 44099, F-31077 Toulouse, Cedex 4, France; Université de Toulouse, UPS, INPT, F-31077 Toulouse, Cedex 4, France.
Remi ChauvinCNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, BP 44099, F-31077 Toulouse, Cedex 4, France; Université de Toulouse, UPS, INPT, F-31077 Toulouse, Cedex 4, France.
Eduardo Henrique Silva SousaDepartamento de Química Orgânica e Inorgânica, Grupo de Bioinorgânica, Universidade Federal do Ceará-UFC, P.O Box 6021, Fortaleza, CE CEP 60440-900, Brazil. Electronic address: eduardohss@dqoi.ufc.br.
Luiz Gonzaga de França LopesDepartamento de Química Orgânica e Inorgânica, Grupo de Bioinorgânica, Universidade Federal do Ceará-UFC, P.O Box 6021, Fortaleza, CE CEP 60440-900, Brazil. Electronic address: lopeslu@dqoi.ufc.br.
Universidade Federal do Ceará · BRInstitut National Polytechnique de Toulouse · FRNational Cancer Institute · USUniversidade Estadual do Ceará · BRUniversidade Federal do Rio Grande do Norte · BRUniversidade de São Paulo · BRUniversité Toulouse III - Paul Sabatier · FR

Funding

Redox Mechanism Process of Nos2 and COX2 in Stroma tumor interactionZIABC010898 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WINK, DAVID · 2009 to 2025
$8.6M
Intramural NIH HHS ZIA BC010898
6 · The paper itself

Abstract

Nitric oxide (NO) and nitroxyl (HNO) have gained broad attention due to their roles in several physiological and pathophysiological processes. Remarkably, these sibling species can exhibit opposing effects including the promotion of angiogenic activity by NO compared to HNO, which blocks neovascularization. While many NO donors have been developed over the years, interest in HNO has led to the recent emergence of new donors. However, in both cases there is an expressive lack of iron-based compounds. Herein, we explored the novel chemical reactivity and stability of the trans-[Fe(cyclam)(NO)Cl]Cl

Indexed as

Angiogenesis InhibitorsAnimalsCell Line, TumorCoordination ComplexesGlutathioneHumansHypoxia-Inducible Factor 1, alpha SubunitIronMiceNitric OxideNitric Oxide DonorsNitrogen OxidesRatsTemperatureUltraviolet RaysVasodilator AgentsAngiogenesis InhibitorsCoordination ComplexesGlutathioneHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitIronNitric OxideNitric Oxide DonorsNitrogen OxidesnitroxylVasodilator AgentsAnti-angiogenesisIron complexNitric oxideNitroxylVasodilation

Identifiers

PMID32619898
PMCPMC8998159
OpenAlexW3036035915

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.