Evidence map›Paper›PMID 32619834›Full record

ArticleUltrasonics2020

Minimally invasive therapeutic ultrasound: Ultrasound-guided ultrasound ablation in neuro-oncology.

Micah Belzberg, Smruti Mahapatra, Alexander Perdomo-Pantoja, Francisco Chavez, Kyle Morrison, Kah Timothy Xiong, Nao J Gamo, Stephen Restaino, Nitish Thakor, Youseph Yazdi and 8 more

Open access · greenAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasonics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Surgical Management of Brain Tumors with Focused Ultrasound.Current oncology (Toronto, Ont.) · 2023
    Review
  3. Review
  4. Article
  5. A MINIATURE LASER SPECKLE CONTRAST IMAGER FOR MONITORING OF THE NEURO-MODULATORY EFFECT OF TRANSCRANIAL FOCUSED ULTRASOUND STIMULATION.Proceedings of the ... Design of Medical Devices Conference. Design of Medical Devices Conference · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Micah BelzbergDepartment of Dermatology, Johns Hopkins University, Baltimore, MD, USA.
Smruti MahapatraDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Alexander Perdomo-PantojaDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Francisco ChavezSonic Concepts, Inc., Bothell, WA, USA.
Kyle MorrisonSonic Concepts, Inc., Bothell, WA, USA.
Kah Timothy XiongSonic Concepts, Inc., Bothell, WA, USA.
Nao J GamoMaryland Development Center, Baltimore, MD, USA.
Stephen RestainoMaryland Development Center, Baltimore, MD, USA.
Nitish ThakorDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Youseph YazdiDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Rajiv IyerDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Betty TylerDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Nicholas TheodoreDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Mark G LucianoDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Henry BremDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Mari GrovesDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Alan R CohenDepartment of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
Amir ManbachiDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA. Electronic address: Amir.Manbachi@jhu.edu.
Johns Hopkins University · USSonic Concepts (United States) · US

Funding

Institutional Career Development CoreKL2TR003099 · NCATS · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2019 to 2023
$7.9M
NCATS NIH HHS KL2 TR003099
6 · The paper itself

Abstract

introductionTo improve patient outcomes (eg, reducing blood loss and infection), practitioners have gravitated toward noninvasive and minimally invasive surgeries (MIS), which demand specialized toolkits. Focused ultrasound, for example, facilitates thermal ablation from a distance, thereby reducing injury to surrounding tissue. Focused ultrasound can often be performed noninvasively; however, it is more difficult to carry out in neuro-oncological tumors, as ultrasound is dramatically attenuated while propagating through the skull. This shortcoming has prompted exploration of MIS options for intracranial placement of focused ultrasound probes, such as within the BrainPath™ (NICO Corporation, Indianapolis, IN). Herein, we present the design, development, and in vitro testing of an image-guided, focused ultrasound prototype designed for use in MIS procedures. This probe can ablate neuro-oncological lesions despite its small size. MATERIALS &

methodsPreliminary prototypes were iteratively designed, built, and tested. The final prototype consisted of three 8-mm-diameter therapeutic elements guided by an imaging probe. Probe functionality was validated on a series of tissue-mimicking phantoms.

resultsLesions were created in tissue-mimicking phantoms with average dimensions of 2.5 × 1.2 × 6.5 mm and 3.4 × 3.25 × 9.36 mm after 10- and 30-second sonification, respectively. 30 s sonification with 118 W power at 50% duty cycle generated a peak temperature of 68 °C. Each ablation was visualized in real time by the built-in imaging probe.

conclusionWe developed and validated an ultrasound-guided focused ultrasound probe for use in MIS procedures. The dimensional constraints of the prototype were designed to reflect those of BrainPath trocars, which are MIS tools used to create atraumatic access to deep-seated brain pathologies.

Indexed as

TransducersUltrasonography, InterventionalBrain DiseasesEquipment DesignHigh-Intensity Focused Ultrasound AblationHumansPhantoms, ImagingAblationAcoustic probesEngineering designFocused ultrasoundMinimally invasive surgeryNeurosurgeryOncologyTherapeutic ultrasoundTransducer designUltrasound

Identifiers

PMID32619834
PMCPMC8895244
OpenAlexW3036228449

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.