Evidence map›Paper›PMID 32619811›Full record

ArticleCellular immunology2020

IL-7 receptor alpha defines heterogeneity and signature of human effector memory CD8

Min Sun Shin, Dongjoo Kim, Kristina Yim, Hong-Jai Park, Sungyong You, Xuemei Dong, Fotios Koumpouras, Albert C Shaw, Rong Fan, Smita Krishnaswamy and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Min Sun ShinDepartments of Internal Medicine and Yale University School of Medicine, New Haven, CT 06520, USA.
Dongjoo KimDepartment of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.
Kristina YimDepartments of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
Hong-Jai ParkDepartments of Internal Medicine and Yale University School of Medicine, New Haven, CT 06520, USA.
Sungyong YouDivision of Cancer Biology and Therapeutics, Departments of Surgery, Biomedical Sciences and Pathology and Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Xuemei DongDepartments of Internal Medicine and Yale University School of Medicine, New Haven, CT 06520, USA.
Fotios KoumpourasDepartments of Internal Medicine and Yale University School of Medicine, New Haven, CT 06520, USA.
Albert C ShawDepartments of Internal Medicine and Yale University School of Medicine, New Haven, CT 06520, USA.
Rong FanDepartment of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.
Smita KrishnaswamyDepartments of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
Insoo KangDepartments of Internal Medicine and Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: Insoo.kang@yale.edu.
Yale University · USCedars-Sinai Medical Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Albert C Shaw · 2002 to 2026
$37.9M
The Impact of Aging and HIV Infection on Immunologic and Transcriptomic Signatures of Influenza Vaccine ResponseR01AG055362 · NIA · YALE UNIVERSITY · PI KANG, INSOO, SHAW, ALBERT C · 2017 to 2021
$4.0M
Studying the impact of altered CD8+ T cell immunity in Alzheimer's diseaseR01AG056728 · NIA · YALE UNIVERSITY · PI KANG, INSOO · 2018 to 2022
$2.3M
Midcareer Award in Translational Immunology of AgingK24AG042489 · NIA · YALE UNIVERSITY · PI SHAW, ALBERT C · 2012 to 2022
$1.8M
Studying lupus Th17 cell characteristics and their modulations by IL-27R21AI126604 · NIAID · YALE UNIVERSITY · PI KANG, INSOO · 2016 to 2017
$461k
Aging and IL-7-Mediated CD8+ T Cell SurvivalR56AG028069 · NIA · YALE UNIVERSITY · PI KANG, INSOO · 2015 to 2015
$416k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R21 AI126604NIA NIH HHS K24 AG042489NIA NIH HHS P30 AG021342NIA NIH HHS R01 AG055362NIA NIH HHS R01 AG056728NIA NIH HHS R56 AG028069
6 · The paper itself

Abstract

The IL-7 receptor alpha chain (IL-7Rα or CD127) can be differentially expressed in memory CD8

Indexed as

AdultCD8-Positive T-LymphocytesFemaleFlow CytometryHumansImmunologic MemoryInterleukin-7 Receptor alpha SubunitMaleSequence Analysis, RNASingle-Cell AnalysisIL7R protein, humanInterleukin-7 Receptor alpha SubunitEffector memory CD8(+) T cellsHigh-dimensional single cell analysisHumanIL-7 receptor

Identifiers

PMID32619811
PMCPMC7415611
OpenAlexW3038075739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.