Evidence map›Paper›PMID 32619508›Full record

ArticleCell stem cell2020

One for All: A Pooled Approach to Classify Functional Impacts of Multiple Mutations.

Alexandre Jourdon, Flora M Vaccarino

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexandre JourdonChild Study Center, Yale University, New Haven, CT 06520, USA.
Flora M VaccarinoChild Study Center, Yale University, New Haven, CT 06520, USA; Department of Neuroscience, Yale University, New Haven, CT 06520, USA. Electronic address: flora.vaccarino@yale.edu.
Yale University · US

Funding

Neurobiology of Autism With MacrocephalyR01MH109648 · NIMH · YALE UNIVERSITY · PI VACCARINO, FLORA M · 2016 to 2021
$3.3M
Engineering of organoid-based brain circuitsRF1MH123978 · NIMH · YALE UNIVERSITY · PI LEVCHENKO, ANDRE, VACCARINO, FLORA M · 2020 to 2020
$1.6M
1/3 Chromatin regulation during brain development and in ASDR56MH114911 · NIMH · YALE UNIVERSITY · PI VACCARINO, FLORA M · 2018 to 2018
$551k
NIMH NIH HHS R01 MH109648NIMH NIH HHS R56 MH114911
6 · The paper itself

Abstract

Understanding common biological consequences of heterogenous mutations in complex polygenic conditions is challenging. In this issue of Cell Stem Cell, Cederquist et al. (2020) implement an in vitro pooled assay where 30 high-confidence ASD mutations engineered in subclones of a human pluripotent stem cell line can be investigated in parallel to reveal their effects on prefrontal cortex neurogenesis.

Indexed as

Autistic DisorderInduced Pluripotent Stem CellsPluripotent Stem CellsHumansMutationNeurogenesis

Identifiers

PMID32619508
OpenAlexW3038838892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.