ArticleCritical care medicine2020
Prevalence and Course of Frailty in Survivors of Critical Illness.
Article in Critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 73 citations in OpenAlex.
- Trauma as a critical condition in the very old: assessment, care pathways and outcome differences.European geriatric medicine · 2026Review
- Sepsis accelerates frailty and functional decline in older adults: a 12-month prospective study.Internal and emergency medicine · 2026Article
- In-hospital development of new-onset frailty and discharge outcomes among patients with sepsis: a Korean multicenter registry study.Journal of intensive care · 2026Article
- Frailty as an Emerging Concern in Post-Extubated Patients: Are We Missing a Critical Window for Recovery?Nursing in critical care · 2026Article
- A Multi-Modal Mobile Phone-Based Communication Strategy to Maximize Retention in a Post-Intensive Care Follow-up Study of Acute Respiratory Distress Syndrome Survivors.Research square · 2026Article
- Current strategies and future directions to enhance recovery following critical illness.Thorax · 2026Review
- Physical, psychological, and cognitive function and quality of life in survivors of severe critical illness.Scientific reports · 2026Article
- Challenges and strategies in the care of older adults across the continuum of intensive and post-intensive care medicine.Intensive care medicine · 2026Review
- Long-term frailty trajectory in older ICU survivors requiring mechanical ventilation: a prospective cohort study in Norway.Annals of intensive care · 2026Article
- Transitions and determinants of ICU-acquired frailty after critical illness: A multicenter cohort study using a multistate Markov model.Annals of intensive care · 2026Article
- In a prospective population-based study, the degree of mobility impairment during hospitalisation is associated with higher degrees of frailty.Aging clinical and experimental research · 2025Article
- Long-term recovery of sensorimotor functions and prediction of participation in survivors of critical illness: a prospective cohort study.Journal of intensive care · 2025Article
- Allostatic overload as the pathophysiological basis for integrating palliative care in the Intensive Care Unit.Intensive care medicine · 2025Article
- Revisiting the Gateway Drug Hypothesis for Cannabis: A Secondary Analysis of a Nationwide Survey Among Community Users in Japan.Neuropsychopharmacology reports · 2025Article
- Construction and validation of a risk prediction model for postoperative frailty in older adults:a multicenter study.BMC geriatrics · 2025Article
- Exploring the Landscape of Social and Economic Factors in Critical Illness Survivorship: A Scoping Review.Critical care explorations · 2025Article
- Survivorship After Cardiogenic Shock.Circulation · 2025Review
- Post-Intensive Care Syndrome: Physical Impairments and Function.Critical care clinics · 2025Review
- Frailty as a predictor of poor outcomes in patients with chronic subdural hematoma (cSDH): A systematic review of literature.World neurosurgery: X · 2024Review
- Frailty is crucial in FORECASTing outcomes in critical care.Intensive care medicine · 2024Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesLittle is known about frailty that develops following critical illness. We sought to describe the prevalence of newly acquired frailty, its clinical course, and the co-occurrence of frailty with disability and cognitive impairment in survivors of critical illness.
designLongitudinal prospective cohort study.
settingMedical and surgical ICUs at five U.S. centers. PATIENTS: Adult patients treated for respiratory failure and/or shock. MEASUREMENTS AND MAIN
resultsWe measured frailty with the Clinical Frailty Scale at baseline (i.e., study enrollment) and at 3 and 12 months postdischarge. We constructed alluvial diagrams to describe the course of frailty and Venn diagrams to describe the overlap of frailty with disability in activities of daily living and cognitive impairment. We included 567 participants a median (interquartile range) of 61 years old (51-70 yr old) with a high severity of illness (Acute Physiology and Chronic Health Evaluation II of 23). Frailty (Clinical Frailty Scale scores ≥ 5) was present in 135 of 567 (24%) at baseline, 239 of 530 (45%) at 3 months, and 163 of 445 (37%) at 12 months. Of those with frailty at 3- or 12-month follow-up, 61% were not frail at baseline. Transition to a worse frailty state occurred in 242 of 530 of patients (46%) between baseline and 3 months and in 179 of 445 of patients (40%) between baseline and 12 months. There were 376 patients with frailty, disability, or cognitive impairment at 3-month follow-up. Of these, 53 (14%) had frailty alone. At 12 months, 276 patients had frailty, disability, or cognitive impairment, 37 (13%) of whom had frailty alone.
conclusionsFrailty is common among survivors of critical illness. In the majority, frailty is newly acquired. Roughly one in seven had frailty without co-occurring disability or cognitive impairment. Studies to understand outcomes of frailty that develops as the result of a critical illness and to identify modifiable risk factors for this potentially reversible syndrome are needed.
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