Evidence map›Paper›PMID 32618513›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2020

Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca

Paul Robinson, Alexander J Sparrow, Suketu Patel, Marta Malinowska, Svetlana N Reilly, Yin-Hua Zhang, Barbara Casadei, Hugh Watkins, Charles Redwood

Erratum issuedOpen access · hybridAbstract readComparative Study
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Comparing the effects of chemical CaJournal of molecular and cellular cardiology · 2023
    Article
  6. Review
  7. Case Report: Mutation inFrontiers in pediatrics · 2023
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Paul RobinsonDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Alexander J SparrowDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Suketu PatelDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Marta MalinowskaDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Svetlana N ReillyDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Yin-Hua ZhangDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Barbara CasadeiDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-6801-1617
Hugh WatkinsDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-5287-9016
Charles RedwoodDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
British Heart Foundation · GB

Funding

British Heart Foundation CH/12/3/29609British Heart Foundation CH/1992001/6764British Heart Foundation FS/16/5/32054British Heart Foundation PG/18/68/33883British Heart Foundation RE/13/1/30181British Heart Foundation RG/07/012/24110British Heart Foundation RG/12/16/29939British Heart Foundation RG/16/12/32451British Heart Foundation (BHF) CH/1992001/6764British Heart Foundation (BHF) PG/18/68/33883British Heart Foundation (BHF) RE/13/1/30181British Heart Foundation (BHF) RG/12/16/29939
6 · The paper itself

Abstract

Dilated cardiomyopathy (DCM) is clinically characterized by dilated ventricular cavities and reduced ejection fraction, leading to heart failure and increased thromboembolic risk. Mutations in thin-filament regulatory proteins can cause DCM and have been shown in vitro to reduce contractility and myofilament Ca

Indexed as

Calcium SignalingMutationMyocardial ContractionVentricular Function, LeftAnimalsCardiomyopathy, DilatedCardiomyopathy, HypertrophicCells, CulturedGenetic Predisposition to DiseaseGuinea PigsMaleMicrofilament ProteinsMyocytes, CardiacNFATC Transcription FactorsOncogene Protein v-aktPhenotypeMicrofilament ProteinsNFATC Transcription FactorsOncogene Protein v-aktSarcoplasmic Reticulum Calcium-Transporting ATPasesSodium-Calcium ExchangerTropomyosinTroponin ITroponin TAktcalciumcardiomyopathyNFAT transcription factorRAC-α serine/threonine-protein kinasetropomyosintroponin

Identifiers

PMID32618513
PMCPMC7473929
OpenAlexW3039154538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.