Observational studyExperimental dermatology2021
Prognostic tools for hypertrophic scar formation based on fundamental differences in systemic immunity.
Observational study in Experimental dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Microbiome and Inflammatory Biomarkers Associated With Palatal Wound Healing.Journal of periodontal research · 2025Trial
- Review
- Development of a predictive model for the relationship between serum pan-immunoinflammatory index levels and scar formation in facial burn patients.American journal of translational research · 2025Article
- NRP1 transduces mechanical stress inhibition via LATS1/YAP in hypertrophic scars.Cell death discovery · 2023Article
- [Expression of microRNA-296 in rabbit hypertrophic scars and its role to human fibroblasts].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Article
- The Bigger Picture: Why Oral Mucosa Heals Better Than Skin.Biomolecules · 2021Review
- [Expression and effect of microRNA-627 in human hypertrophic scar].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Article
- Prognostic tools for hypertrophic scar formation based on fundamental differences in systemic immunity.Experimental dermatology · 2021Observational
- More than just bricks and mortar: Fibroblasts and ECM in skin health and disease.Experimental dermatology · 2021Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unpredictable hypertrophic scarring (HS) occurs after approximately 35% of all surgical procedures and causes significant physical and psychological complaints. Parallel to the need to understanding the mechanisms underlying HS formation, a prognostic tool is needed. The objective was to determine whether (systemic) immunological differences exist between patients who develop HS and those who develop normotrophic scars (NS) and to assess whether those differences can be used to identify patients prone to developing HS. A prospective cohort study with NS and HS groups in which (a) cytokine release by peripheral blood mononuclear cells (PBMC) and (b) the irritation threshold (IT) after an irritant (sodium lauryl sulphate) patch test was evaluated. Univariate regression analysis of PBMC cytokine secretion showed that low MCP-1, IL-8, IL-18 and IL-23 levels have a strong correlation with HS (P < .010-0.004; AUC = 0.790-0.883). Notably, combinations of two or three cytokines (TNF-a, MCP-1 and IL-23; AUC: 0.942, Nagelkerke R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.