Evidence map›Paper›PMID 32617854›Full record

ArticleNeurotoxicity research2020

Transcription Factors Phox2a/2b Upregulate Expression of Noradrenergic and Dopaminergic Phenotypes in Aged Rat Brains.

Yan Fan, Fei Zeng, Russell W Brown, Jennifer B Price, Thomas C Jones, Meng-Yang Zhu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicity research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Yan FanDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Fei ZengDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Russell W BrownDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Jennifer B PriceDepartment of Biological Sciences, College of Arts and Sciences, East Tennessee State University, Johnson City, TN, USA.
Thomas C JonesDepartment of Biological Sciences, College of Arts and Sciences, East Tennessee State University, Johnson City, TN, USA.
Meng-Yang ZhuDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA. zhum@etsu.edu.ORCID http://orcid.org/0000-0002-5403-1270
East Tennessee State University · US

Funding

Restoration of noradrenergic and dopaminergic functions in the brain of aged rats.R15AG055107 · NIA · EAST TENNESSEE STATE UNIVERSITY · PI ZHU, MENG-YANG · 2018 to 2018
$444k
NIA NIH HHS R15 AG055107NIH HHS AG055107
6 · The paper itself

Abstract

The present study investigated the effects of forced overexpression of Phox2a/2b, two transcription factors, in the locus coeruleus (LC) of aged rats on noradrenergic and dopaminergic phenotypes in brains. Results showed that a significant increase in Phox2a/2b mRNA levels in the LC region was paralleled by marked enhancement in expression of DBH and TH per se. Furthermore, similar increases in TH protein levels were observed in the substantial nigra and striatum, as well as in the hippocampus and frontal cortex. Overexpression of Phox2 genes also significantly increased BrdU-positive cells in the hippocampal dentate gyrus and NE levels in the striatum. Moreover, this manipulation significantly improved the cognition behavior. The in vitro experiments revealed that norepinephrine treatments may increase the transcription of TH gene through the epigenetic action on the TH promoter. The results indicate that Phox2 genes may play an important role in improving the function of the noradrenergic and dopaminergic neurons in aged animals, and regulation of Phox2 gene expression may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.

Indexed as

AgingAnimalsDopamineFemaleMaleNerve Tissue ProteinsNeuronsNorepinephrinePromoter Regions, GeneticRats, Inbred F344Substantia NigraTranscriptional ActivationTranscription FactorsTyrosine 3-MonooxygenaseDopamineNerve Tissue ProteinsNorepinephrineTranscription FactorsTyrosine 3-MonooxygenaseDopamineDopamine-β-hydroxylaseLocus coeruleusMorris water mazeNeurogenesisTyrosine hydroxylase

Identifiers

PMID32617854
PMCPMC7484387
OpenAlexW3040528102

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.