Evidence map›Paper›PMID 32617778›Full record

ArticleAIDS and behavior2021

Alcohol Use and Antiretroviral Adherence Among Patients Living with HIV: Is Change in Alcohol Use Associated with Change in Adherence?

Emily C Williams, Kathleen A McGinnis, Anna D Rubinsky, Theresa E Matson, Jennifer F Bobb, Gwen T Lapham, E Jennifer Edelman, Derek D Satre, Sheryl L Catz, Julie E Richards and 9 more

Abstract read
In one paragraph

Article in AIDS and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Emily C WilliamsHealth Services Research & Development (HSR&D), Center of Innovation for Veteran-Centered Value-Driven Care, Veteran Affairs (VA) Puget Sound Health Care System, 1660 S. Columbian Way, S-152, Seattle, WA, 98108, USA. emily.williams3@va.gov.ORCID http://orcid.org/0000-0002-8210-6137
Kathleen A McGinnisVeterans Aging Cohort Study Coordinating Center, VA Connecticut Healthcare System, West Haven, CT, USA.
Anna D RubinskyHealth Services Research & Development (HSR&D), Center of Innovation for Veteran-Centered Value-Driven Care, Veteran Affairs (VA) Puget Sound Health Care System, 1660 S. Columbian Way, S-152, Seattle, WA, 98108, USA.
Theresa E MatsonHealth Services Research & Development (HSR&D), Center of Innovation for Veteran-Centered Value-Driven Care, Veteran Affairs (VA) Puget Sound Health Care System, 1660 S. Columbian Way, S-152, Seattle, WA, 98108, USA.
Jennifer F BobbKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Gwen T LaphamHealth Services Research & Development (HSR&D), Center of Innovation for Veteran-Centered Value-Driven Care, Veteran Affairs (VA) Puget Sound Health Care System, 1660 S. Columbian Way, S-152, Seattle, WA, 98108, USA.
E Jennifer EdelmanSchools of Medicine and Public Health, Yale University, New Haven, CT, USA.
Derek D SatreDepartment of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Sheryl L CatzBetty Irene Moore School of Nursing, University of California at Davis, Sacramento, CA, USA.
Julie E RichardsDepartment of Health Services, University of Washington, Seattle, WA, USA.
Kendall J BryantNational Institute On Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Brandon D L MarshallDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Kevin L KraemerDivision of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Stephen CrystalHealth Services Research, Rutgers University, New Brunswick, NJ, USA.
Adam J GordonDivision of Epidemiology, Department of Internal Medicine, Program for Addiction Research, Clinical Care, Knowledge and Advocacy (PARCKA), University of Utah School of Medicine, Salt Lake City, UT, USA.
Melissa SkandersonVeterans Aging Cohort Study Coordinating Center, VA Connecticut Healthcare System, West Haven, CT, USA.
David A FiellinVeterans Aging Cohort Study Coordinating Center, VA Connecticut Healthcare System, West Haven, CT, USA.
Amy C JusticeVeterans Aging Cohort Study Coordinating Center, VA Connecticut Healthcare System, West Haven, CT, USA.
Katharine A BradleyHealth Services Research & Development (HSR&D), Center of Innovation for Veteran-Centered Value-Driven Care, Veteran Affairs (VA) Puget Sound Health Care System, 1660 S. Columbian Way, S-152, Seattle, WA, 98108, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Alcohol Associated Outcomes Among HIV+/- Aging VeteransU10AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2006 to 2010
$12.7M
Alcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7M
Sex Disparities in Overall Response to ART Among HIV Infected IndividualsU24AA020794 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$5.5M
Integrated Stepped Care for Unhealthy Alcohol Use in HIVU01AA020795 · NIAAA · YALE UNIVERSITY · PI FIELLIN, DAVID · 2011 to 2020
$5.2M
Consortium to improve Outcomes in HIV/AIDS, Alcohol, Aging & multi-Substance useU01AA020799 · NIAAA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BRAITHWAITE, RONALD SCOTT · 2011 to 2020
$2.1M
Mentoring alcohol use intervention research in HIV health care settingsK24AA025703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Derek D Satre · 2018 to 2026
$1.8M
Training Clinicians in Implementation Research to Improve Alcohol-related CareK24AA022128 · NIAAA · KAISER FOUNDATION RESEARCH INSTITUTE · PI BRADLEY, KATHARINE ANTHONY · 2016 to 2020
$876k
Alcohol-related Care & Outcomes for Outpatients with HIV in a National VA CohortR21AA022866 · NIAAA · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI BRADLEY, KATHARINE ANTHONY, WILLIAMS, EMILY CATERINA · 2015 to 2016
$434k
Implementation Research for Evidence-based Care for Alcohol DependenceIK2HX001161 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI WILLIAMS, EMILY CATERINA · 2015 to 2015
–
HSRD VA IK2 HX001161NCATS NIH HHS UL1 TR001863NIAAA NIH HHS K24 AA022128NIAAA NIH HHS K24AA022128NIAAA NIH HHS K24 AA025703NIAAA NIH HHS K24AA025703NIAAA NIH HHS R21 AA022866NIAAA NIH HHS R21AA022866-01NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U01AA020790NIAAA NIH HHS U01 AA020795NIAAA NIH HHS U01AA020795NIAAA NIH HHS U01 AA020799NIAAA NIH HHS U01AA020799NIAAA NIH HHS U10 AA013566NIAAA NIH HHS U10AA013566NIAAA NIH HHS U24 AA020794NIAAA NIH HHS U24AA020794U.S. Department of Veterans Affairs CDA 12-276
6 · The paper itself

Abstract

Alcohol use increases non-adherence to antiretroviral therapy (ART) among persons living with HIV (PLWH). Dynamic longitudinal associations are understudied. Veterans Aging Cohort Study (VACS) data 2/1/2008-7/31/16 were used to fit linear regression models estimating changes in adherence (% days with ART medication fill) associated with changes in alcohol use based on annual clinically-ascertained AUDIT-C screening scores (range - 12 to + 12, 0 = no change) adjusting for demographics and initial adherence. Among 21,275 PLWH (67,330 observations), most reported no (48%) or low-level (39%) alcohol use initially, with no (55%) or small (39% ≤ 3 points) annual change. Mean initial adherence was 86% (SD 21%), mean annual change was - 3.1% (SD 21%). An inverted V-shaped association was observed: both increases and decreases in AUDIT-C were associated with greater adherence decreases relative to stable scores [p < 0.001, F (4, 21,274)]. PLWH with dynamic alcohol use (potentially indicative of alcohol use disorder) should be considered for adherence interventions.

Indexed as

Alcohol DrinkingAnti-Retroviral AgentsHIV InfectionsMedication AdherenceAgedCohort StudiesFemaleHumansMaleMiddle AgedAnti-Retroviral AgentsAdherenceAlcohol useAntiretroviral therapyARTHIV

Identifiers

PMID32617778
PMCPMC7775874

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.