ArticleInternational journal of legal medicine2020
A novel approach for the forensic diagnosis of drowning by microbiological analysis with next-generation sequencing and unweighted UniFrac-based PCoA.
Article in International journal of legal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Differentiating hemorrhagic shock and organophosphate poisoning through integrated skin microbiome-metabolome signatures.BMC microbiology · 2026Article
- Association of Intratumoral Microbiota Modulation with Prostate Cancer Progression: A Microbiome Analysis of Prostatic Tissue.Biomedicines · 2025Article
- Microbiota signature of the lung as the promising bioindicator for drowning diagnosis and postmortem submersion interval estimation.International journal of legal medicine · 2025Article
- Antiepileptic Effects ofBiology · 2025Article
- Microbial community profiling for forensic drowning diagnosis across locations and submersion times.BMC microbiology · 2025Article
- A fundamental study on postmortem submersion interval estimation by metabolomics analyzing of gastrocnemius muscle from submersed rat models in freshwater.International journal of legal medicine · 2024Article
- Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis.International journal of molecular sciences · 2024Article
- Forensic Microbiology: When, Where and How.Microorganisms · 2024Review
- Exploring the characteristics of gut microbiome in patients of Southern Fujian with hypocitraturia urolithiasis and constructing clinical diagnostic models.International urology and nephrology · 2023Article
- Finding phylogeny-aware and biologically meaningful averages of metagenomic samples: L2UniFrac.Bioinformatics (Oxford, England) · 2023Article
- Biochemical Recurrence in Prostate Cancer Is Associated with the Composition ofInternational journal of molecular sciences · 2023Article
- Finding phylogeny-aware and biologically meaningful averages of metagenomic samples:bioRxiv : the preprint server for biology · 2023Article
- Article
- Trends in forensic microbiology: From classical methods to deep learning.Frontiers in microbiology · 2023Review
- Inference of drowning sites using bacterial composition and random forest algorithm.Frontiers in microbiology · 2023Article
- Next-Generation Sequencing Results Vary Between Cultured and Uncultured Microbes.Current microbiology · 2022Article
- A preliminary study on early postmortem submersion interval (PMSI) estimation and cause-of-death discrimination based on nontargeted metabolomics and machine learning algorithms.International journal of legal medicine · 2022Article
- Epidemiological Analysis of Drowning Deaths Among Different Groups in Jordan - a Retrospective Study (2015-2019).Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022Article
- Postmortem submersion interval estimation of cadavers recovered from freshwater based on gut microbial community succession.Frontiers in microbiology · 2022Article
- Microbial communities in the liver and brain are informative for postmortem submersion interval estimation in the late phase of decomposition: A study in mouse cadavers recovered from freshwater.Frontiers in microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
The diagnosis of drowning is one of the major challenges in forensic practice, especially when the corpse is in a state of decomposition. Novel indicators of drowning are desired in the field of forensic medicine. In the past decade, aquatic bacteria have attracted great attention from forensic experts because they can easily enter the blood circulation with drowning medium, and some of them can proliferate in the corpse. Recently, the advent of next-generation sequencing (NGS) has created new opportunities to efficiently analyze whole microbial communities and has catalyzed the development of forensic microbiology. We presumed that NGS could be a potential method for diagnosing drowning. In the present study, we verified this hypothesis by fundamental experiments in drowned and postmortem-submersed rat models. Our study revealed that detecting the bacterial communities with NGS and processing the data in a transparent way with unweighted UniFrac-based principal coordinates analysis (PCoA) could clearly discriminate the skin, lung, blood, and liver specimens of the drowning group and postmortem submersion group. Furthermore, the acquired information could be used to identify new cases. Taken together, these results suggest that we could build a microbial database of drowned and postmortem-submersed victims by NGS and subsequently use a bioinformatic method to diagnose drowning in future forensic practice.
Indexed as
Identifiers
32617663What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.