Evidence map›Paper›PMID 32617189›Full record

ArticlePeerJ2020

Whole genome sequencing analysis identifies recurrent structural alterations in esophageal squamous cell carcinoma.

Munmee Dutta, Hidewaki Nakagawa, Hiroaki Kato, Kazuhiro Maejima, Shota Sasagawa, Kaoru Nakano, Aya Sasaki-Oku, Akihiro Fujimoto, Raúl Nicolás Mateos, Ashwini Patil and 5 more

Open access · goldAbstract read
In one paragraph

Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  5. Alterations inContemporary oncology (Poznan, Poland) · 2025
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Munmee DuttaDepartment of Computational Biology and Medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo, Chiba, Japan.
Hidewaki NakagawaLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Hiroaki KatoDepartment of Surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Kazuhiro MaejimaLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Shota SasagawaLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Kaoru NakanoLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Aya Sasaki-OkuLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Akihiro FujimotoDepartment of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Raúl Nicolás MateosDepartment of Computational Biology and Medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo, Chiba, Japan.
Ashwini PatilHuman Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Hiroko TanakaHuman Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Satoru MiyanoHuman Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Takushi YasudaDepartment of Surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Kenta NakaiDepartment of Computational Biology and Medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo, Chiba, Japan.
Masashi FujitaLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
RIKEN Center for Integrative Medical Sciences · JPThe University of Tokyo · JPKindai University · JPKyoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) is the predominant type of esophageal cancer in the Asian region, including Japan. A previous study reported mutational landscape of Japanese ESCCs by using exome sequencing. However, somatic structural alterations were yet to be explored. To provide a comprehensive mutational landscape, we performed whole genome sequencing (WGS) analysis of biopsy specimens from 20 ESCC patients in a Japanese population. WGS analysis identified non-silent coding mutations of

Indexed as

Coding mutationCopy number alterationDruggable geneEsophageal squamous cell carcinomaFAT1FGFR1LRP1BMutational signatureStructural variationWhole genome sequencing

Identifiers

PMID32617189
PMCPMC7323713
OpenAlexW3037622134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.