Evidence map›Paper›PMID 32617130›Full record

ArticleOxidative medicine and cellular longevity2020

Inhibitory Effect of Ursolic Acid on Ultraviolet B Radiation-Induced Oxidative Stress and Proinflammatory Response-Mediated Senescence in Human Skin Dermal Fibroblasts.

Ramachandran Samivel, Rajendra Prasad Nagarajan, Umadevi Subramanian, Adnan Ali Khan, Ali Masmali, Turki Almubrad, Saeed Akhtar

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
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  4. Article
  5. Journal of microbiology and biotechnology · 2025
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  10. Molecules (Basel, Switzerland) · 2024
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  14. Exploiting the Integrated Valorization ofInternational journal of molecular sciences · 2023
    Article
  15. Conditioned Medium from HAntioxidants (Basel, Switzerland) · 2022
    Article
  16. Review
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ramachandran SamivelCornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Saudi Arabia.
Rajendra Prasad NagarajanDepartment of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamil Nadu, India.
Umadevi SubramanianTranslational Research Platform for Veterinary Biologicals, Central University Laboratory Building, TANUVAS, Tamil Nadu, India.
Adnan Ali KhanCornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Saudi Arabia.
Ali MasmaliCornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Saudi Arabia.ORCID https://orcid.org/0000-0001-5992-6332
Turki AlmubradCornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Saudi Arabia.
Saeed AkhtarCornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Saudi Arabia.ORCID https://orcid.org/0000-0002-4056-1449
King Saud University · SAAnnamalai University · INTranslational Research Platform for Veterinary Biologicals (India) · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultraviolet radiation is an environmental carcinogenic agent that enhances inflammation and immunological reactions in the exposed human skin cells leading to oxidative photoaging of the epidermal and dermal segment. In the present study, we investigated the protective role of ursolic acid (UA) against ultraviolet B (UVB) radiation- induced photoaging an

Indexed as

Cellular SenescenceUltraviolet Raysbcl-2-Associated X ProteinCaspase 3Cell NucleusCell SurvivalDermisDNA DamageFibroblastsHumansInflammationMatrix Metalloproteinase 2Matrix Metalloproteinase 9Membrane Potential, MitochondrialNF-kappa BOxidative Stressbcl-2-Associated X ProteinCaspase 3Matrix Metalloproteinase 2Matrix Metalloproteinase 9NF-kappa BReactive Oxygen SpeciesRNA, MessengerThiobarbituric Acid Reactive SubstancesTriterpenesTumor Necrosis Factor-alphaTumor Suppressor Protein p53Ursolic Acid

Identifiers

PMID32617130
PMCPMC7313156
OpenAlexW3034958219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.