Evidence map›Paper›PMID 32617116›Full record

ArticleComputational and mathematical methods in medicine2020

Construction and Comprehensive Analysis of Dysregulated Long Noncoding RNA-Associated Competing Endogenous RNA Network in Moyamoya Disease.

Xuefeng Gu, Dongyang Jiang, Yue Yang, Peng Zhang, Guoqing Wan, Wangxian Gu, Junfeng Shi, Liying Jiang, Bing Chen, Yanjun Zheng and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and mathematical methods in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Xuefeng GuResearch Department, Shanghai University of Medicine & Health Science Affiliated Zhoupu Hospital, Shanghai, China.ORCID https://orcid.org/0000-0002-8718-2067
Dongyang JiangDepartment of Cardiology, Pan-Vascular Medicine Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Yue YangKey Laboratory of Cancer Prevention and Treatment of Heilongjiang Province, Mudanjiang Medical University, Mudanjiang, China.
Peng ZhangSchool of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, China.ORCID https://orcid.org/0000-0002-9997-2576
Guoqing WanResearch Department, Shanghai University of Medicine & Health Science Affiliated Zhoupu Hospital, Shanghai, China.
Wangxian GuShanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Junfeng ShiShanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Liying JiangShanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Bing ChenDepartment of Neurosurgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Yanjun ZhengShanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Dingsheng LiuDepartment of Oncology and Hematology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, China.ORCID https://orcid.org/0000-0003-2712-0988
Sufen GuoKey Laboratory of Cancer Prevention and Treatment of Heilongjiang Province, Mudanjiang Medical University, Mudanjiang, China.ORCID https://orcid.org/0000-0003-2828-5266
Changlian LuShanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai, China.ORCID https://orcid.org/0000-0002-0812-9162
Shanghai University of Medicine and Health Sciences · CNMudanjiang Medical University · CNGuangdong Medical College · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMoyamoya disease (MMD) is a rare cerebrovascular disease characterized by chronic progressive stenosis or occlusion of the bilateral internal carotid artery (ICA), the anterior cerebral artery (ACA), and the middle cerebral artery (MCA). MMD is secondary to the formation of an abnormal vascular network at the base of the skull. However, the etiology and pathogenesis of MMD remain poorly understood.

methodsA competing endogenous RNA (ceRNA) network was constructed by analyzing sample-matched messenger RNA (mRNA), long non-coding RNA (lncRNA), and microRNA (miRNA) expression profiles from MMD patients and control samples. Then, a protein-protein interaction (PPI) network was constructed to identify crucial genes associated with MMD. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analyses were employed with the DAVID database to investigate the underlying functions of differentially expressed mRNAs (DEmRNAs) involved in the ceRNA network. CMap was used to identify potential small drug molecules.

resultsA total of 94 miRNAs, 3649 lncRNAs, and 2294 mRNAs were differentially expressed between MMD patients and control samples. A synergistic ceRNA lncRNA-miRNA-mRNA regulatory network was constructed. Core regulatory miRNAs (miR-107 and miR-423-5p) and key mRNAs (STAT5B, FOSL2, CEBPB, and CXCL16) involved in the ceRNA network were identified. GO and KEGG analyses indicated that the DEmRNAs were involved in the regulation of the immune system and inflammation in MMD. Finally, two potential small molecule drugs, CAY-10415 and indirubin, were identified by CMap as candidate drugs for treating MMD.

conclusionsThe present study used bioinformatics analysis of candidate RNAs to identify a series of clearly altered miRNAs, lncRNAs, and mRNAs involved in MMD. Furthermore, a ceRNA lncRNA-miRNA-mRNA regulatory network was constructed, which provides insights into the novel molecular pathogenesis of MMD, thus giving promising clues for clinical therapy.

Indexed as

Case-Control StudiesComputational BiologyDatabases, Nucleic AcidDatabases, PharmaceuticalGene Expression ProfilingGene Expression RegulationGene OntologyGene Regulatory NetworksHumansIndolesMicroRNAsMolecular Sequence AnnotationMoyamoya DiseaseProtein Interaction MapsRNA, Long NoncodingRNA, MessengerCAY10415indirubinIndolesMicroRNAsRNA, Long NoncodingRNA, MessengerThiazolidinediones

Identifiers

PMID32617116
PMCPMC7306867
OpenAlexW3034440044

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.