Evidence map›Paper›PMID 32616946›Full record

ArticleThe Canadian journal of hospital pharmacy

Prescribing Patterns and Patient Outcomes for Bone and Joint Infections Treated with Cefazolin and Probenecid: A Retrospective Observational Study.

Marci E Dearing, Sarah V Burgess, Valerie Murphy, Samuel Campbell, Lynn Johnston, Tasha D Ramsey

Open access · bronzeAbstract read

In one paragraph

Article in The Canadian journal of hospital pharmacy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 46% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Marci E Dearing, RPh, BSc(Pharm), ACPR, PharmD, is with the Pharmacy Department, Nova Scotia Health Authority, Halifax, Nova Scotia.

Sarah V Burgess, RPh, BSc(Pharm), ACPR, PharmD, is with the Pharmacy Department, Nova Scotia Health Authority, and the College of Pharmacy, Faculty of Health, Dalhousie University, Halifax, Nova Scotia.

Valerie Murphy, RPh, BSc(Pharm), ACPR, is with the Pharmacy Department, Nova Scotia Health Authority, Halifax, Nova Scotia.

Samuel Campbell, MB BCh, CCFP(EM), DipPEC(SA), FCCHL, is with the Department of Emergency Medicine, Charles V Keating Emergency and Trauma Centre, Central Zone, Nova Scotia Health Authority, Halifax, Nova Scotia.

Lynn Johnston, MD, MSc, FRCPC, is with the Division of Infectious Diseases, Central Zone, Nova Scotia Health Authority, Halifax, Nova Scotia.

Tasha D Ramsey, RPh, BSc(Pharm), ACPR, PharmD, is with the Pharmacy Department, Nova Scotia Health Authority, and the College of Pharmacy, Faculty of Health, Dalhousie University, Halifax, Nova Scotia.

Nova Scotia Health Authority · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have described the use of cefazolin with probenecid to treat uncomplicated skin and soft-tissue infections. Some prescribers are extrapolating from this evidence to treat more invasive infections, which have a greater potential for poor outcomes, including treatment failure that could lead to increased morbidity and mortality. Information supporting cefazolin with probenecid as effective treatment in this context is needed.

objectivesTo describe prescribing patterns and outcomes for patients who received cefazolin with probenecid for the treatment of bone and joint infections.

methodsThis single-centre retrospective study involved adult outpatients for whom cefazolin and probenecid were prescribed for bone and joint infections between April 1, 2012, and March 31, 2017. Patient charts were reviewed, and data were collected for clinical and microbiological variables using a standardized data collection form.

resultsIn a total of 80 cases, the patient received cefazolin and probenecid for treatment of a bone or joint infection, of which 69 cases met the inclusion criteria. In most cases (

conclusionsThe effectiveness of cefazolin and probenecid for the treatment of bone and joint infections appears to be similar to that of standard treatment, as reported in the literature. Antibiotic effectiveness is difficult to determine conclusively in a retrospective analysis, so these results should be interpreted with caution, but they may stimulate further research.

Indexed as

bone infectioncefazolinjoint infectionoutpatient parenteral antimicrobial therapyprobenecid

Identifiers

PMID32616946

PMCPMC7308159

OpenAlexW3040509635

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.