ReviewOncogene2020
Pathomechanisms in schwannoma development and progression.
Review in Oncogene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Surgical Management of Craniovertebral Junction Schwannomas: A Systematic Review.Current oncology (Toronto, Ont.) · 2022Pooled it
- Clinicopathological features of esophageal schwannomas in mainland China: systematic review of the literature.International journal of clinical oncology · 2021Pooled it
- Para-aortic retroperitoneal robotic assisted laparoscopic schwannoma excision.Journal of surgical case reports · 2026Article
- Peripheral nerve sheath tumors-on-a-chip: Next-generation platforms for mechanistic and therapeutic studies.Materials today. Advances · 2026Article
- Fimepinostat Promotes Apoptosis and Decreases Cytokine Secretion inInternational journal of molecular sciences · 2026Article
- High frequency of mosaic NF2-related schwannomatosis diagnosed after somatic analysis of multi-nodular schwannomas in schwannomatosis patients.Human genetics · 2026Article
- Oral-maxillofacial and cervical schwannomas: a retrospective cohort analysis with a rare intraosseous case.BMC oral health · 2026Article
- Review
- Schwannomatosis tumor modeling: progress and prospects for translational research.Journal of biological engineering · 2026Review
- T-cell-targeted immunotherapy in neurofibromatosis type 2-related vestibular schwannoma: current evidence and future direction.Brain communications · 2026Review
- Endoscopic-assisted low-temperature plasma resection of tongue root schwannoma via oral approach: a case report and literature review.Frontiers in pediatrics · 2026Article
- BET proteins mediate survival mechanisms in human schwannoma model cells challenged with trametinib but not brigatinib.Oncogene · 2025Article
- Gallbladder Schwannoma: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2025Article
- Breast schwannoma: review of entity and differential diagnosis.Journal of pathology and translational medicine · 2025Article
- High-Grade Angiosarcoma Transformation in Schwannoma and SMARCB1 Mutation: A Case Report.The American journal of case reports · 2025Article
- Soft tissue myxofibrosarcoma in the right lower limb: a case report.Journal of medical case reports · 2025Article
- Pathologic and Therapeutic Schwann Cells.Cells · 2025Review
- Lip Schwannoma-A Rare Presentation in a Pediatric Patient: Case Report and a Literature Review.Diagnostics (Basel, Switzerland) · 2025Article
- Tongue Schwannoma at the Median Inferior Surface in the Elderly: A Case Report.Clinical case reports · 2025Article
- Optic nerve sheath schwannoma: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schwannomas are tumors of the peripheral nervous system, consisting of different cell types. These include tumorigenic Schwann cells, axons, macrophages, T cells, fibroblasts, blood vessels, and an extracellular matrix. All cell types involved constitute an intricate "tumor microenvironment" and play relevant roles in the development and progression of schwannomas. Although Nf2 tumor suppressor gene-deficient Schwann cells are the primary tumorigenic element and principle focus of current research efforts, evidence is accumulating regarding the contributory roles of other cell types in schwannoma pathology. In this review, we aim to provide an overview of intra- and intercellular mechanisms contributing to schwannoma formation. "Genes load the gun, environment pulls the trigger." -George A. Bray.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.