ArticleScientific reports2020
Normal aging changes in the choroidal angioarchitecture of the macula.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Choroidal vascularity index is independent of ocular and image-based factors in healthy eyes: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Choroidal vascularity across aging and the spectrum of age-related macular degeneration: an AI-based OCT study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Association between arterial stiffness and choroidal vascular in type 2 diabetes: more pronounced in individuals aged 30 to 50 years.International ophthalmology · 2026Article
- Ocular microvascular changes in hypoestrogenism: an OCT/OCTA systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Spatial Selective Choroidal Stromal and Vascular Changes in Intermediate AMD: Insights From High-Density Optical Coherence Tomography Analysis.Investigative ophthalmology & visual science · 2026Article
- A multimodal retinal aging clock for biological age prediction and systemic health assessment via OCT and fundus imaging.Scientific reports · 2026Article
- HIF1 activity in photoreceptors drives type 3 neovascularization and retinal atrophy in a new mouse model of age-related macular degeneration.Cell death & disease · 2025Article
- Age-Related Regional Changes in Choroidal Vascularity in Healthy Emmetropic Eyes.Translational vision science & technology · 2025Article
- Exploring the impact of age and gender on retinal and choroidal thickness and vascular densities: a comprehensive analysis.International journal of retina and vitreous · 2025Article
- Choroidal imaging biomarkers as predictors of conversion to exudative age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Genetic influence on choroidal vascularity index.PloS one · 2025Article
- Choroidal vascularity index in health and systemic diseases: a systematic review.International journal of retina and vitreous · 2024Review
- Age related grid-wise spatial analysis of choroidal parameters in well characterised healthy population.Scientific reports · 2024Article
- Aging in Ocular Blood Vessels: Molecular Insights and the Role of Oxidative Stress.Biomedicines · 2024Review
- Quantitative Evaluation of the Topographical Maps of Three-Dimensional Choroidal Vascularity Index in Children With Different Degrees of Myopia.Investigative ophthalmology & visual science · 2024Article
- Characterisation of the normal human ganglion cell-inner plexiform layer using widefield optical coherence tomography.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2024Article
- Validation of reliability, repeatability and consistency of three-dimensional choroidal vascular index.Scientific reports · 2024Article
- Choroidal Changes in Rhesus Macaques in Aging and Age-Related Drusen.Investigative ophthalmology & visual science · 2023Article
- Quantitative assessment of the choroidal vasculature in myopic macular degeneration with optical coherence tomographic angiography.Frontiers in ophthalmology · 2023Article
- Does senescence play a role in age-related macular degeneration?Experimental eye research · 2022Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The choroidal vascularity index (CVI) has been shown to be sensitive in detecting changes in choroidal angioarchitecture in a range of ocular diseases. However, changes in CVI in association with normal physiological aging and spatial distribution remains to be determined. This is significant as a range of ocular conditions with choroidal degeneration are associated with aging. In this study, we assessed CVI for 106 healthy eyes from 106 individuals (range 21-78 years old, ~ 20 individuals/decade) at 15 eccentricities across the macula (0, 230 µm, 460 µm, 690 µm, 1,150 µm, 1,380 µm and 2,760 µm from the fovea in the superior and inferior direction). Total choroidal area, luminal area and stromal area were all significantly decreased with age (p < 0.001 for all parameters). CVI was also significantly decreased with age (p < 0.01) and eccentricity. Fitting of quadratic regression curves to CVI as a function of age yielded a good fit for all eccentricities (r
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Registered trials
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