ArticleScientific reports2020
Functional organization of mouse primary auditory cortex in adult C57BL/6 and F1 (CBAxC57) mice.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 62 citations in OpenAlex.
- Layer 6 corticothalamic neurons show diverse and dynamic responses that support a role in cortical gain control in noisy environments.bioRxiv : the preprint server for biology · 2026Article
- Psilocybin Attenuates Cortical Representations of Aversion in the Mouse Auditory Cortex.bioRxiv : the preprint server for biology · 2026Article
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- Aging in the Primary Auditory Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
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- Rapid rebalancing of co-tuned ensemble activity in the auditory cortex.bioRxiv : the preprint server for biology · 2025Article
- Patchy harmonic functional connectivity of the mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Limiting Hearing Loss in Transgenic Mouse Models.eNeuro · 2025Article
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- Automated head-fixation training system with high levels of animal participation in psychoacoustic tasks.PloS one · 2025Article
- Sparse representation of neurons for encoding complex sounds in the auditory cortex.Progress in neurobiology · 2024Article
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- Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity.Cell reports · 2024Article
- Topography and Ensemble Activity in the Auditory Cortex of a Mouse Model of Fragile X Syndrome.eNeuro · 2024Article
- Auditory cortex conveys non-topographic sound localization signals to visual cortex.Nature communications · 2024Article
- Long-term training alters response dynamics in the aging auditory cortex.Hearing research · 2024Article
- Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics.Cell reports · 2024Article
- Fractured columnar small-world functional network organization in volumes of L2/3 of mouse auditory cortex.PNAS nexus · 2024Article
- Orbitofrontal cortex conveys stimulus and task information to the auditory cortex.Current biology : CB · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The primary auditory cortex (A1) plays a key role for sound perception since it represents one of the first cortical processing stations for sounds. Recent studies have shown that on the cellular level the frequency organization of A1 is more heterogeneous than previously appreciated. However, many of these studies were performed in mice on the C57BL/6 background which develop high frequency hearing loss with age making them a less optimal choice for auditory research. In contrast, mice on the CBA background retain better hearing sensitivity in old age. Since potential strain differences could exist in A1 organization between strains, we performed comparative analysis of neuronal populations in A1 of adult (~ 10 weeks) C57BL/6 mice and F1 (CBAxC57) mice. We used in vivo 2-photon imaging of pyramidal neurons in cortical layers L4 and L2/3 of awake mouse primary auditory cortex (A1) to characterize the populations of neurons that were active to tonal stimuli. Pure tones recruited neurons of widely ranging frequency preference in both layers and strains with neurons in F1 (CBAxC57) mice exhibiting a wider range of frequency preference particularly to higher frequencies. Frequency selectivity was slightly higher in C57BL/6 mice while neurons in F1 (CBAxC57) mice showed a greater sound-level sensitivity. The spatial heterogeneity of frequency preference was present in both strains with F1 (CBAxC57) mice exhibiting higher tuning diversity across all measured length scales. Our results demonstrate that the tone evoked responses and frequency representation in A1 of adult C57BL/6 and F1 (CBAxC57) mice are largely similar.
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