Evidence map›Paper›PMID 32616759›Full record

ArticleScientific reports2020

Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature.

Anish K Simhal, Kimberly L H Carpenter, Saad Nadeem, Joanne Kurtzberg, Allen Song, Allen Tannenbaum, Guillermo Sapiro, Geraldine Dawson

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Curvature on Graphs with Negative Edge Weights.IEEE transactions on network science and engineering · 2026
    Article
  3. Review
  4. A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Anish K Simhal *Department of Electrical and Computer Engineering, Duke University, Durham, USA. aksimhal@gmail.com.ORCID http://orcid.org/0000-0001-7848-3565
Kimberly L H Carpenter *Department of Psychiatry and Behavioral Sciences, Duke Center for Autism and Brain Development, Duke University School of Medicine, Durham, USA.
Saad Nadeem *Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.ORCID http://orcid.org/0000-0001-5030-9792
Joanne KurtzbergMarcus Center for Cellular Cures, Duke University Medical Center, Durham, USA.
Allen SongBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Allen TannenbaumDepartment of Computer Science, Stony Brook University, Stony Brook, USA.
Guillermo SapiroDepartment of Electrical and Computer Engineering, Duke University, Durham, USA.
Geraldine DawsonDepartment of Psychiatry and Behavioral Sciences, Duke Center for Autism and Brain Development, Duke University School of Medicine, Durham, USA.ORCID http://orcid.org/0000-0003-1410-2764
Duke University · USDuke Medical Center · USMemorial Sloan Kettering Cancer Center · USStony Brook University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Scalable Computational Platform For Active Closed-Loop Behavioral Coding in Autism Spectrum DisorderR01MH120093 · NIMH · DUKE UNIVERSITY · PI DAWSON, GERALDINE, SAPIRO, GUILLERMO R · 2019 to 2022
$1.6M
NCI NIH HHS P30 CA008748NIMH NIH HHS R01 MH120093
6 · The paper itself

Abstract

Ollivier-Ricci curvature is a method for measuring the robustness of connections in a network. In this work, we use curvature to measure changes in robustness of brain networks in children with autism spectrum disorder (ASD). In an open label clinical trials, participants with ASD were administered a single infusion of autologous umbilical cord blood and, as part of their clinical outcome measures, were imaged with diffusion MRI before and after the infusion. By using Ricci curvature to measure changes in robustness, we quantified both local and global changes in the brain networks and their potential relationship with the infusion. Our results find changes in the curvature of the connections between regions associated with ASD that were not detected via traditional brain network analysis.

Indexed as

Autism Spectrum DisorderBlood Transfusion, AutologousChild, PreschoolDiffusion Magnetic Resonance ImagingFemaleFetal BloodHumansMaleNerve NetWhite Matter

Identifiers

PMID32616759
PMCPMC7331646
OpenAlexW3040653702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.