Evidence map›Paper›PMID 32616653›Full record

ArticleThe Journal of biological chemistry2020

Structural and catalytic roles of the human 18

Hui Shen, Julian Stoute, Kathy Fange Liu

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
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  9. Ghost authors revealed: The structure and function of human NWiley interdisciplinary reviews. RNA · 2023
    Review
  10. Noncatalytic regulation of 18Genes & development · 2023
    Article
  11. Biological roles of adenine methylation in RNA.Nature reviews. Genetics · 2023
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hui ShenDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Julian StouteDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Kathy Fange LiuDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: liufg@pennmedicine.upenn.edu.
University of Pennsylvania · US

Funding

Structural biology and molecular biophysics training programT32GM132039 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Ben E. Black, Elizabeth Rhoades · 2019 to 2026
$3.3M
Coregulation of mRNA, tRNA, and rRNA species through RNA modificationsR35GM133721 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LIU, FANGE · 2019 to 2023
$2.5M
NIGMS NIH HHS R35 GM133721NIGMS NIH HHS T32 GM132039
6 · The paper itself

Abstract

rRNA-modifying enzymes participate in ribosome assembly. However, whether the catalytic activities of these enzymes are important for the ribosome assembly and other cellular processes is not fully understood. Here, we report the crystal structure of WT human dimethyladenosine transferase 1 (DIMT1), an 18

Indexed as

Protein BiosynthesisAmino Acid SubstitutionCatalysisCrystallography, X-RayHEK293 CellsHumansMethyltransferasesMutation, MissenseRibosome Subunits, Small, EukaryoticRNA, Ribosomal, 18SDIMT1 protein, humanMethyltransferasesRNA, Ribosomal, 18S18S rRNAcancercatalytic roledimethyladenosine transferase 1 (DIMT1)DIMT1 E85ADNA damage responseenzymeribosome assemblyribosome biogenesisRNA methylationRNA-modifying enzymerRNAstructural biologytranslation controltranslation fidelity

Identifiers

PMID32616653
PMCPMC7443495
OpenAlexW3039779832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.