ArticleAJNR. American journal of neuroradiology2020
Intraluminal Carotid Artery Thrombus in COVID-19: Another Danger of Cytokine Storm?
Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Special report of the RSNA COVID-19 task force: systematic review of outcomes associated with COVID-19 neuroimaging findings in hospitalized patients.The British journal of radiology · 2021Pooled it
- The association of smoking status with SARS-CoV-2 infection, hospitalization and mortality from COVID-19: a living rapid evidence review with Bayesian meta-analyses (version 7).Addiction (Abingdon, England) · 2021Pooled it
- Stroke as a Neurological Complication of COVID-19: A Systematic Review and Meta-Analysis of Incidence, Outcomes and Predictors.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021Pooled it
- Heterogeneity in Regional Damage Detected by Neuroimaging and Neuropathological Studies in Older Adults With COVID-19: A Cognitive-Neuroscience Systematic Review to Inform the Long-Term Impact of the Virus on Neurocognitive Trajectories.Frontiers in aging neuroscience · 2021Pooled it
- COVID-19 and Cerebrovascular Diseases: A Systematic Review and Perspectives for Stroke Management.Frontiers in neurology · 2020Pooled it
- COVID-19 Pathophysiology Predicts That Ischemic Stroke Occurrence Is an Expectation, Not an Exception-A Systematic Review.Frontiers in neurology · 2020Pooled it
- Acute Ischemic Stroke and Endovascular Thrombectomy During COVID-19 Pandemic: A Nationwide Analysis.Neurosurgery practice · 2025Article
- Post COVID-19 condition is associated with altered regional cerebral blood volume as revealed by dynamic susceptibility contrast MRI.Frontiers in neuroimaging · 2025Article
- Brain functional connectivity alterations associated with neuropsychological performance 6-9 months following SARS-CoV-2 infection.Human brain mapping · 2023Article
- The effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on ischemic stroke and the possible underlying mechanisms.The International journal of neuroscience · 2023Article
- Acute Neurological Complications of Coronavirus Disease.Neuroimaging clinics of North America · 2023Review
- Vascular Implications of COVID-19: Role of Radiological Imaging, Artificial Intelligence, and Tissue Characterization: A Special Report.Journal of cardiovascular development and disease · 2022Review
- Long-COVID diagnosis: From diagnostic to advanced AI-driven models.European journal of radiology · 2022Review
- Outcome and characteristics of COVID-19 patients associated with stroke: a multicenter hospital-based study in Egypt.The Egyptian journal of neurology, psychiatry and neurosurgery · 2022Article
- Simultaneous Pulmonary Embolism and Carotid Thrombosis as a Presenting Manifestation of COVID-19.Case reports in neurological medicine · 2022Article
- Functional connectivity underlying cognitive and psychiatric symptoms in post-COVID-19 syndrome: is anosognosia a key determinant?Brain communications · 2022Article
- Intraluminal carotid thrombosis and acute ischemic stroke associated with COVID-19.Journal of neurology · 2021Article
- Do Elevated Levels of Inflammatory Biomarkers Predict the Risk of Occurrence of Ischemic Stroke in SARS-CoV2 ?: An Observational Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021Observational
- Coronavirus disease 2019 and stroke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2021Article
- Symptomatic Carotid Artery Thrombosis in a Patient Recently Recovered From a COVID-19 Infection.Cureus · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus disease 2019 (COVID-19) is associated with a severe inflammatory response. Inflammation affects atherosclerotic plaque vulnerability and promotes a thrombogenic environment. We report a series of 6 patients with COVID-19 with acute ischemic stroke due to intraluminal carotid artery thrombus presenting during an 8-day period. Six patients were included (5 men) with a mean age of 65.8 years (range, 55-78 years). COVID-19 was diagnosed by detection of Severe Acute Respiratory Syndrome coronavirus 2 in 5 patients and was presumed due to typical clinical and imaging findings in 1 patient. All patients had vascular risk factors including diabetes (83%), hyperlipidemia (100%), and smoking (17%). Four patients presented with large infarcts with initial NIHSS scores of 24-30. During their hospitalization, all patients had elevated D-dimer and C-reactive protein levels, 5 patients had elevated lactate dehydrogenase and ferritin levels, 3 had elevated interleukin-6 levels, and 2 had elevated troponin levels. Inflammation related to COVID-19 may result in rupture of vulnerable atherosclerotic plaques, resulting in thrombosis and acute ischemic stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.