Evidence map›Paper›PMID 32616521›Full record

ArticleDisease models & mechanisms2020

Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of

Craig M Keenan, Lorenzo Ramos-Mucci, Ioannis Kanakis, Peter I Milner, Andrew Leask, David Abraham, George Bou-Gharios, Blandine Poulet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Targeting CCN Proteins in Rheumatoid Arthritis and Osteoarthritis.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Craig M KeenanDepartment of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building, West Derby Street, Liverpool L7 8TX, UK.ORCID 0000-0002-8782-8016
Lorenzo Ramos-MucciDepartment of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building, West Derby Street, Liverpool L7 8TX, UK.
Ioannis KanakisDepartment of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building, West Derby Street, Liverpool L7 8TX, UK.ORCID 0000-0001-6410-1482
Peter I MilnerDepartment of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building, West Derby Street, Liverpool L7 8TX, UK.ORCID 0000-0002-5293-2438
Andrew LeaskCollege of Dentistry, University of Saskatchewan, Saskatoon, SK S7N 5E4, Canada.
David AbrahamCentre for Rheumatology and Connective Tissue Diseases, University College London, London NW3 2PF, UK.ORCID 0000-0001-8952-6057
George Bou-GhariosDepartment of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building, West Derby Street, Liverpool L7 8TX, UK.
Blandine PouletDepartment of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building, West Derby Street, Liverpool L7 8TX, UK b.poulet@liverpool.ac.uk.ORCID 0000-0002-9224-5253
University of Liverpool · GBUniversity College London · GBUniversity of Saskatchewan · CA

Funding

Medical Research Council G0801052Medical Research Council MR/P020941/1Medical Research Council MR/R502182/1Versus Arthritis 20717Versus Arthritis 20859
6 · The paper itself

Abstract

CCN2 is a matricellular protein involved in several crucial biological processes. In particular, CCN2 is involved in cartilage development and in osteoarthritis.

Indexed as

AnimalsCartilage, ArticularChondrocytesChondrogenesisConnective Tissue Growth FactorDisease Models, AnimalGene DeletionMaleMice, Inbred C57BLMice, KnockoutOsteoarthritisStress, MechanicalTime FactorsCCN2 protein, mouseConnective Tissue Growth FactorCartilageCCN2OsteoarthritisPost-traumaticTransgenic mouseTrauma-induced

Identifiers

PMID32616521
PMCPMC7375478
OpenAlexW3039193521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.