ArticleGenes & development2020
A role for alternative splicing in circadian control of exocytosis and glucose homeostasis.
Erratum issuedOpen access · diamondAbstract read
In one paragraph
Article in Genes & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
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0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 30 citations in OpenAlex.
- Review
- A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration.Life science alliance · 2026Article
- Functional role of THRAP3 in modulating thyroid hormone-mediated gene networks in C2C12 myotubes.PloS one · 2026Article
- Cryptochrome interaction networks across different tissues in Drosophila melanogaster.Biology direct · 2025Article
- HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes.Cell metabolism · 2025Article
- A splice site variant in MADD affects hormone expression in pancreatic β cells and pituitary gonadotropes.JCI insight · 2024Article
- Clock-dependent chromatin accessibility rhythms regulate circadian transcription.PLoS genetics · 2024Article
- Interorgan rhythmicity as a feature of healthful metabolism.Cell metabolism · 2024Review
- Alternative splicing and related RNA binding proteins in human health and disease.Signal transduction and targeted therapy · 2024Review
- Repression of latent NF-κB enhancers by PDX1 regulates β cell functional heterogeneity.Cell metabolism · 2024Article
- In vitro evaluation of exocytosis-associated SNARE molecules in human granulosa cells in polycystic ovary syndrome.Journal of assisted reproduction and genetics · 2024Article
- Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain.Journal of neurochemistry · 2023Review
- The physiology of alternative splicing.Nature reviews. Molecular cell biology · 2023Review
- Nova1 or Bim Deficiency in Pancreatic β-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice.Nutrients · 2022Article
- Circadian NAD(P)(H) cycles in cell metabolism.Seminars in cell & developmental biology · 2022Review
- Maturation of beta cells: lessons from in vivo and in vitro models.Diabetologia · 2022Review
- Article
- Genetic Pathways Associated With Sleep Problems in Children With Autism Spectrum Disorder.Frontiers in psychiatry · 2022Article
- The Circadian Clock and Obesity.Handbook of experimental pharmacology · 2022Article
- The Importance of Keeping Time in the Liver.Endocrinology · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 3 institutions in 2 countries.
Biliana Marcheva *Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Mark Perelis *Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Benjamin J Weidemann *Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Akihiko TaguchiDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Haopeng LinDepartment of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Chiaki OmuraDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Yumiko KobayashiDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Marsha V NewmanDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Eugene J WyattCenter for Genetic Medicine, Northwestern University, Chicago, Illinois 60611, USA.
Elizabeth M McNallyCenter for Genetic Medicine, Northwestern University, Chicago, Illinois 60611, USA.
Jocelyn E Manning FoxDepartment of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Heekyung HongDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Archana ShankarDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Emily C WheelerDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Kathryn Moynihan RamseyDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Patrick E MacDonaldDepartment of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Gene W YeoDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Joseph BassDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Northwestern University · USUniversity of California, San Diego · USUniversity of Alberta · CA
Funding
SLOW WAVE SLEEP AND TYPE 2 DIABETES RISK IN AGINGP01AG011412 · NIA · UNIVERSITY OF CHICAGO · PI TUREK, FRED W · 1994 to 2021
$31.5MTRANSGENIC COREP60DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI BELL, GRAEME I · 1985 to 2012
$25.5MTraining and education CoreU54AR052646 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MCNALLY, ELIZABETH M, SWEENEY, H LEE · 2005 to 2020
$24.1MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0MPilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9MFunctional RNA elements in the human genomeR01HG004659 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett, Eugene Wei-Ming Yeo · 2008 to 2026
$12.4MTRAINING GRANT IN SLEEP RESEARCHT32HL007909 · NHLBI · NORTHWESTERN UNIVERSITY · PI FRED W TUREK, Phyllis C. Zee · 1998 to 2026
$9.2MTraining Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6MSARCOGLYCAN IN MYOPATHY AND MUSCLE MEMBRANE STABILITYR01HL061322 · NHLBI · UNIVERSITY OF CHICAGO · PI MCNALLY, ELIZABETH M · 1999 to 2022
$7.5MIntegration of Feeding Time and Glucose Metabolism by the Circadian Gene NetworkR01DK090625 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH, LERNER, TALIA NEWCOMBE · 2011 to 2025
$6.9MPDX-1,A TRANSCRIPTIONAL ACTIVATOR OF THE INSULIN GENER01DK050203 · NIDDK · VANDERBILT UNIVERSITY · PI BASS, JOSEPH, STEIN, ROLAND W · 1995 to 2020
$6.8MTRAINING IN METABOLISM, DIABETES AND ENDOCRINOLOGYT32DK007169 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Joseph Bass · 1988 to 2026
$6.6MCIHRNHGRI NIH HHS R01 HG004659NHLBI NIH HHS F32 HL143978NHLBI NIH HHS R01 HL061322NHLBI NIH HHS T32 HL007909NIA NIH HHS P01 AG011412NIDDK NIH HHS F30 DK116481NIDDK NIH HHS P60 DK020595NIDDK NIH HHS R01 DK090625NIDDK NIH HHS R01 DK100814NIDDK NIH HHS R01 DK113011NIDDK NIH HHS T32 DK007169
Abstract
The circadian clock is encoded by a negative transcriptional feedback loop that coordinates physiology and behavior through molecular programs that remain incompletely understood. Here, we reveal rhythmic genome-wide alternative splicing (AS) of pre-mRNAs encoding regulators of peptidergic secretion within pancreatic β cells that are perturbed in
Indexed as
Alternative SplicingExocytosisAnimalsARNTL Transcription FactorsCells, CulturedCircadian ClocksCLOCK ProteinsDeath Domain Receptor Signaling Adaptor ProteinsGlucoseGuanine Nucleotide Exchange FactorsGuanylate KinasesHomeostasisInsulin-Secreting CellsInsulin SecretionIslets of LangerhansMaleARNTL Transcription FactorsBmal1 protein, mouseCASK kinasesClock protein, mouseCLOCK ProteinsDeath Domain Receptor Signaling Adaptor ProteinsGlucoseGuanine Nucleotide Exchange FactorsGuanylate KinasesMadd protein, mouseNuclear ProteinsSnap25 protein, mouseSynaptosomal-Associated Protein 25Thrap3 protein, mouseTranscription Factorsalternative splicingCASKcircadian clockexocytosisinsulin secretionMADDRNA sequencingSNAP25THRAP3transcriptomics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.