Evidence map›Paper›PMID 32616504›Full record

ArticleBiology open2020

Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway.

Jaroslav Fabik, Katarina Kovacova, Zbynek Kozmik, Ondrej Machon

Open access · goldAbstract read
In one paragraph

Article in Biology open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Mechanistic insights into cardiac regeneration and protection through MEIS inhibition.Turkish journal of biology = Turk biyoloji dergisi · 2024
    Article
  6. Article
  7. Orofacial Cleft and Mandibular Prognathism-Human Genetics and Animal Models.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Meis2 controls skeletal formation in the hyoid region.Frontiers in cell and developmental biology · 2022
    Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jaroslav FabikDepartment of Developmental Biology, Institute of Experimental Medicine of the Czech Academy of Sciences, Praha, Czech Republic.
Katarina KovacovaDepartment of Developmental Biology, Institute of Experimental Medicine of the Czech Academy of Sciences, Praha, Czech Republic.
Zbynek KozmikLaboratory of Transcriptional Regulation, Institute of Molecular Genetics of the Czech Academy of Sciences, Praha, Czech Republic.ORCID 0000-0002-5850-2105
Ondrej MachonDepartment of Developmental Biology, Institute of Experimental Medicine of the Czech Academy of Sciences, Praha, Czech Republic ondrej.machon@iem.cas.cz.ORCID 0000-0002-5139-1406
Czech Academy of Sciences, Institute of Experimental Medicine · CZCharles University · CZCzech Academy of Sciences, Institute of Molecular Genetics · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cranial neural crest cells (cNCCs) originate in the anterior neural tube and populate pharyngeal arches in which they contribute to formation of bone and cartilage. This cell population also provides molecular signals for the development of tissues of non-neural crest origin, such as the tongue muscles, teeth enamel or gland epithelium. Here we show that the transcription factor Meis2 is expressed in the oral region of the first pharyngeal arch (PA1) and later in the tongue primordium. Conditional inactivation of

Indexed as

Body PatterningSignal TransductionAllelesAnimalsBiomarkersCalcinosisDental ArchGene DeletionHedgehog ProteinsHomeodomain ProteinsImmunohistochemistryMandibleMiceMice, TransgenicNeural CrestOrganogenesisBiomarkersHedgehog ProteinsHomeodomain ProteinsMrg1 protein, mouseCraniofacialMeisPharyngeal archSonic hedgehog (Shh) signalling

Identifiers

PMID32616504
PMCPMC7331463
OpenAlexW3039269286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.