ArticleBMJ open2020
Sex-specific association of serum uric acid dynamics with the incidence of metabolic syndrome in a health check-up Chinese population: a prospective cohort study.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Investigating the Sexual Dimorphism of Waist-to-Hip Ratio and Its Associations with Complex Traits.Genes · 2025Article
- Association between Glycosylated Hemoglobin and Serum Uric Acid: A US NHANES 2011-2020.International journal of endocrinology · 2024Article
- Prevalence of Hyperuricemia and Its Association with Cardiovascular Risk Factors and Subclinical Target Organ Damage.Journal of clinical medicine · 2022Article
- Interaction of sex and diabetes on the association between hemoglobin glycation index, hemoglobin A1c and serum uric acid.Diabetology & metabolic syndrome · 2022Article
- The bidirectional relationship between metabolic syndrome and hyperuricemia in China: A longitudinal study from CHARLS.Endocrine · 2022Article
- A systematic review and meta-analysis of the correlation between hyperuricemia and thyroid nodules in adults.Gland surgery · 2021Article
- Fructose Induces Visceral Adipose Tissue Inflammation and Insulin Resistance Even Without Development of Obesity in Adult Female but Not in Male Rats.Frontiers in nutrition · 2021Article
- Transition Patterns of Weight Status and Their Predictive Lipid Markers Among Chinese Adults: A Longitudinal Cohort Study Using the Multistate Markov Model.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMany studies have demonstrated that elevated serum uric acid (SUA) level is linked with metabolic syndrome (MetS). However, whether there is a sex difference in the association between SUA and MetS has not been determined. This study aimed to accurately explore the impact of SUA longitudinal changes on MetS by sex.
designA prospective cohort study.
settingThe Health Check-up Centre of the Second Hospital affiliated with Dalian Medical University from 2010 to 2016.
participantsA health check-up cohort of 577 men and 1698 women aged 20-60 years who did not exhibit MetS or hyperuricaemia at baseline and underwent at least two physical examinations from 2010 to 2016. PRIMARY AND SECONDARY OUTCOME MEASURES: Weight, height, blood pressure and blood biochemistry parameters, including SUA, were measured. MetS was defined according to the Joint Interim Statement criteria.
methodsBased on longitudinal data, a linear mixed-effects model was constructed to explore the characteristics of SUA dynamic changes in males and females, and joint modelling of longitudinal and survival data was done to analyse the association between SUA dynamic changes and MetS occurrence.
resultsThe natural logarithm of SUA (LNSUA) in females exhibited a gradually increasing trend, and its annual growth rate in females who developed MetS was greater than that of the non-MetS females. The longitudinal growth of SUA in females was a risk factor for the onset of MetS, and the estimated HR was 13.2580 (95% CI 1.9106 to 91.9957) for each 1-unit rise in LNSUA longitudinally. An association between the longitudinal growth of LNSUA and MetS was not found in males.
conclusionsThe longitudinal increase in SUA in females could increase the risk of MetS, even if the SUA changes within the normal range. The longitudinal increase in SUA in males was not a predictor for MetS.
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