ArticlePoultry science2020
Ammonia induce lung tissue injury in broilers by activating NLRP3 inflammasome via Escherichia/Shigella.
Article in Poultry science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Exploring the chicken respiratory microbiome: a comprehensive meta-analysis of factors shaping chicken respiratory microbiota.Scientific reports · 2026Pooled it
- Identification of microbial markers associated with lung cancer based on multi-cohort 16 s rRNA analyses: A systematic review and meta-analysis.Cancer medicine · 2023Pooled it
- Trial
- Respiratory and Gastrointestinal Microbiome Shifts in Livestock Exposed to High-Ammonia Environments: A Systematic Review.Veterinary sciences · 2026Review
- Impact of Vitamin E, Selenium, and Deferasirox on the Negative Effects of Experimental Coccidiosis.Biological trace element research · 2026Article
- Respiratory microbiota maturation enables machine learning based age prediction in chickens.BMC microbiology · 2026Article
- Integrated metabolome and microbiome analysis deciphers the effects of resveratrol and β-hydroxy-β-methylbutyric acid on jejunal function under different protein levels in Tibetan sheep.Microbiology spectrum · 2026Article
- Selenium-enriched yeast improves gut health in broilers by modulating the gut microbiota-metabolites-intestinal mucosal immunity axis.Journal of animal science · 2026Article
- Aerosol transmission of infectious diseases in poultry: microbiology, pathogenesis, and control measures.Frontiers in microbiology · 2026Review
- Effect ofAnimals : an open access journal from MDPI · 2025Article
- Avian PathogenicVeterinary sciences · 2025Review
- Microbial Ecology of Sulfur Mustard Toxicity: From Dysbiosis to Restoration.Microorganisms · 2025Article
- Honeysuckle-Derived Nanovesicles Regulate Gut Microbiota for the Treatment of Inflammatory Bowel Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multi-Omics Analysis of Gut Microbiome and Host Metabolism in Different Populations of Chinese Alligators (Ecology and evolution · 2025Article
- Decrease in Escherichia-Shigella in the gut microbiota of ESKD patients undergoing maintenance hemodialysis.BMC nephrology · 2025Article
- Alterations in gut-kidney axis indicators and TMAO-related biomarkers in elderly patients with hypertensive nephropathy.Frontiers in medicine · 2025Article
- Ammonia Exposure-Induced Immunological Damage in Chicken Lymphoid Organs via TLR-7/MYD88/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation.Journal of microbiology and biotechnology · 2024Article
- Characteristics and function of the gut microbiota in patients with IgA nephropathy via metagenomic sequencing technology.Renal failure · 2024Article
- Association between gut microbiota and acute upper respiratory tract infection: a Mendelian randomization study.Scientific reports · 2024Article
- Altered gut microbiota is associated with the formation of occult hepatitis B virus infection.Microbiology spectrum · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory tract diseases are closely related to atmosphere pollution. Ammonia is one of the harmful pollutants in the atmosphere environment, which has a great threat to human and animal respiratory tract health, but the mechanism of causing diseases is not clear. In this study, broiler lung tissue was used as a model to study the effect of high ammonia on respiratory tract diseases through the relationship between respiratory microflora, NLRP3 inflammasome, and inflammatory factors. For this, we validated the occurrence of lung tissue inflammation under ammonia exposure and detected the lung tissue microbial constituent by 16S rDNA sequencing. Moreover, the relative expression levels of NLRP3 and caspase-1 mRNA and the content of IL-1β and IL-6 were measured. After 7-D ammonia exposure, the proportion of the phylum Proteobacteria and the genus Escherichia/Shigella in lung tissue was significantly increased, the expression levels of NLRP3 and caspase-1 mRNA were significantly increased, and the content of IL-1β in lung tissue and serum was higher than that in the control group. In conclusion, high ammonia induced lung tissue inflammation via increasing the proportion of Escherichia/Shigella, activating NLRP3 inflammasome, and promoting IL-1β release. These findings provided a reference for the prevention and control of respiratory tract diseases in humans and animals caused by ammonia pollution.
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