ArticleJournal of the American College of Cardiology2020
Pre-Term Delivery and Risk of Ischemic Heart Disease in Women.
Article in Journal of the American College of Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 59 citations in OpenAlex.
- Birth weight of term born offspring in relation to long-term maternal cardiovascular morbidity and mortality.European journal of epidemiology · 2026Article
- Preterm Birth and Maternal Cardiovascular Risk.European cardiology · 2026Review
- Adverse Pregnancy Outcomes and Long-Term Risk of Atrial Fibrillation.JAMA cardiology · 2025Article
- Global, regional, and national burden of ischemic heart disease in young and middle-aged population from 1990 to 2021.Scientific reports · 2025Article
- Adverse pregnancy outcomes and long-term risk of stroke: a Swedish nationwide co-sibling study.European heart journal · 2025Article
- Exposure to low concentrations of PMBMC public health · 2025Article
- Adverse Pregnancy Outcomes and Long-Term Risk of Heart Failure in Women: National Cohort and Co-Sibling Study.JACC. Heart failure · 2025Article
- Pregnancy Complications and Long-Term Atherosclerotic Cardiovascular Disease Risk.Current atherosclerosis reports · 2025Review
- Secular Trends in Preterm Birth Rates: Uncovering the Primary Challenge for Perinatal Medicine in Greece.Cureus · 2024Article
- Pregnancy, Reproductive Factors, and Female Heart Failure Risk and Outcomes.Current heart failure reports · 2024Review
- Differences in Risk Factors for Coronary Atherosclerosis According to Sex.Journal of lipid and atherosclerosis · 2024Review
- Adverse pregnancy outcomes and long-term risk of chronic kidney disease in women: national cohort and co-sibling study.American journal of obstetrics and gynecology · 2024Article
- Pregnancy History at 40 Years of Age as a Marker of Cardiovascular Risk.Journal of the American Heart Association · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Update on sex specific risk factors in cardiovascular disease.Frontiers in cardiovascular medicine · 2024Review
- Impact of adverse pregnancy outcomes on brain vascular health and cognition.Research and practice in thrombosis and haemostasis · 2024Article
- US County-Level Variation in Preterm Birth Rates, 2007-2019.JAMA network open · 2023Article
- Sex Differences in Coronary Artery Disease: Insights From the KoRean wOmen'S chest pain rEgistry (KoROSE).Korean circulation journal · 2023Review
- An international real-world analysis of relapsed/refractory lymphoma occurring during pregnancy.Blood advances · 2023Article
- Preventing Adverse Cardiovascular Outcomes in Pregnancy Complicated by Obesity.Current obstetrics and gynecology reports · 2023Article
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6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWomen who deliver pre-term have been reported to have increased future risks of cardiometabolic disorders. However, their long-term risks of ischemic heart disease (IHD) and whether such risks are due to shared familial factors are unclear. A better understanding of these risks may help improve long-term clinical follow-up and interventions to prevent IHD in women.
objectivesThe purpose of this study was to determine the long-term risks of IHD in women by pregnancy duration.
methodsA national cohort study was conducted of all 2,189,190 women with a singleton delivery in Sweden from 1973 to 2015, who were followed up for IHD through the end of 2015. Cox regression was used to compute adjusted hazard ratios (aHRs) for IHD associated with pregnancy duration, and cosibling analyses assessed the influence of shared familial (genetic and/or environmental) factors.
resultsIn 47.5 million person-years of follow-up, 49,955 (2.3%) women were diagnosed with IHD. In the 10 years following delivery, the aHR for IHD associated with pre-term delivery (<37 weeks) was 2.47 (95% confidence interval [CI]: 2.16 to 2.82), and further stratified was 4.04 (95% CI: 2.69 to 6.08) for extremely pre-term (22 to 27 weeks), 2.62 (95% CI: 2.09 to 3.29) for very pre-term (28 to 33 weeks), 2.30 (95% CI: 1.97 to 2.70) for late pre-term (34 to 36 weeks), and 1.47 (95% CI: 1.30 to 1.65) for early-term (37 to 38 weeks), compared with full-term (39 to 41 weeks). These risks declined but remained significantly elevated after additional follow-up (pre-term vs. full-term, 10 to 19 years: aHR: 1.86; 95% CI: 1.73 to 1.99; 20 to 29 years: aHR: 1.52; 95% CI: 1.45 to 1.59; 30 to 43 years: aHR: 1.38; 95% CI: 1.32 to 1.45). These findings did not appear attributable to shared genetic or environmental factors within families. Additional pre-term deliveries were associated with further increases in risk.
conclusionsIn this large national cohort, pre-term delivery was a strong independent risk factor for IHD. This association waned over time but remained substantially elevated up to 40 years later. Pre-term delivery should be recognized as a risk factor for IHD in women across the life course.
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