ArticleJournal of orthopaedic surgery and research2020
Relationship between the inflammation/immune indexes and deep venous thrombosis (DVT) incidence rate following tibial plateau fractures.
Article in Journal of orthopaedic surgery and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 7 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 7 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Systemic Inflammatory Indexes as Predictors of Delirium, Thromboembolic Events, and Mortality After Hip Fracture and Major Orthopedic Surgery: A Meta-Analysis.Journal of Korean medical science · 2026Pooled it
- Prognostic Role of Blood Inflammatory Composite Biomarkers in Dvt After Lower Extremity Fractures.The Iowa orthopaedic journal · 2026Pooled it
- The risk prediction models for deep venous thrombosis in perioperative patients with lower limb fractures: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2025Pooled it
- Pooled it
- Prevalence of preoperative deep vein thrombosis in long bone fractures of lower limbs: a systematic review and meta-analysis.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2023Pooled it
- Systemic immune-inflammation index as a potential biomarker of cardiovascular diseases: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- The Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for Deep Venous Thrombosis: A Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- In-hospital deep vein thrombosis after tibial plateau fractures: incidence, laterality/anatomy, and risk factors in a multicenter retrospective cohort of 3366 patients.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2026Article
- Association between lymphocyte to high-density lipoprotein ratio and total bone mineral density in 8-19-year-old children and adolescents: a cross-sectional study.European journal of medical research · 2026Article
- Preoperative deep vein thrombosis in tibial plateau fractures: development and internal validation of an interpretable multivariable machine-learning diagnostic model.Frontiers in medicine · 2026Article
- Article
- Comment on Mureșan et al. Prognostic Nutritional Index, Controlling Nutritional Status (CONUT) Score, and Inflammatory Biomarkers as Predictors of Deep Vein Thrombosis, Acute Pulmonary Embolism, and Mortality in COVID-19 Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Correlation of Preoperative Inflammation/Immunity Markers With Postoperative Urinary Tract Infections in Elderly Hip Fracture Patients.Orthopaedic surgery · 2025Article
- Construction of a Nomogram for Portal Vein Thrombosis After Endoscopic Therapy of Severe Gastroesophageal Varices in Cirrhotic Patients.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Incidence of Unapparent Preoperative Deep Vein Thrombosis in Patients with Traumatic Intraarticular Tibial Plateau Fracture.Journal of clinical medicine · 2025Article
- Investigating the dual causative pathways linking immune cells and venous thromboembolism via Mendelian randomization analysis.Thrombosis journal · 2025Article
- Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function.Open medicine (Warsaw, Poland) · 2025Article
- Platelet-to-lymphocyte ratio as a predictor of preoperative venous thrombosis in femoral fracture patients: a retrospective cohort study.Frontiers in cardiovascular medicine · 2025Article
- Deep vein thrombosis in patients with patellar fractures: Assessing incidence rates and identifying risk factors.PloS one · 2025Article
- Neutrophil extracellular trap markers predict thrombotic risk in patients with hyperhomocysteinemia: development and validation of a predictive model.Frontiers in physiology · 2025Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine the relationship between inflammation/immune-based indexes and deep venous thrombosis (DVT) incidence rate following tibial plateau fractures
methodsRetrospective analysis of a prospectively collected data on patients undergoing surgeries of tibial plateau fractures between October 2014 and December 2018 was performed. Duplex ultrasonography (DUS) was routinely used to screen for preoperative DVT of bilateral lower extremities. Data on biomarkers (neutrophil, lymphocyte, monocyte, and platelet counts) at admission were collected, based on which neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte/lymphocyte (MLR), and systemic immune-inflammation index (SII, neutrophil* platelet/lymphocyte) were calculated. Receiver operating characteristic (ROC) was used to determine the optimal cutoff value for each variable. Multivariate logistic regression analysis was used to evaluate the independent relationship of each biomarker or index with DVT, after adjustment for demographics, co-morbidities, and injury-related variables.
resultsAmong 1179 patients included, 16.3% (192/1179) of them had a preoperative DVT. Four factors were identified to be significantly associated with DVT, including open fracture, increased D-dimer level. Among the biomarkers and indexes, only platelet and neutrophil were identified to be independently associated with DVT, and the significance remained after exclusion of open fracture. The other independent variables were elevated D-dimer level (> 0.55 mg/L), male gender, and hypertension in the sensitivity analysis with open fractures excluded.
conclusionThese identified factors are conducive to the initial screening for patients at risk of DVT, individualized risk assessment, risk stratification, and accordingly, development of targeted prevention programs.
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