Evidence map›Paper›PMID 32616045›Full record

ArticleRespiratory research2020

High-dose intranasal application of titanium dioxide nanoparticles induces the systemic uptakes and allergic airway inflammation in asthmatic mice.

Shaza Abdulnasser Harfoush, Matthias Hannig, Duc Dung Le, Sebastian Heck, Maximilian Leitner, Albert Joachim Omlor, Isabella Tavernaro, Annette Kraegeloh, Ralf Kautenburger, Guido Kickelbick and 6 more

Open access · goldAbstract read
In one paragraph

Article in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Advanced Nanostructured Coatings Based on Doped TiOMolecules (Basel, Switzerland) · 2023
    Review
  5. A multiplex inhalation platform to modelFrontiers in pharmacology · 2023
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Shaza Abdulnasser HarfoushDepartment of Experimental Pneumology and Allergology, Faculty of Medicine, Saarland University, Homburg, Germany.
Matthias HannigClinic of Operative Dentistry, Periodontology, and Preventive Dentistry, Saarland University, Homburg, Germany.
Duc Dung LeDepartment of Internal Medicine II, University Hospital, Interdisciplinary Center for Clinical Research Laboratory for Experimental Stem Cell Transplantation, Würzburg, Germany.
Sebastian HeckDepartment of Experimental Pneumology and Allergology, Faculty of Medicine, Saarland University, Homburg, Germany.
Maximilian LeitnerDepartment of Experimental Pneumology and Allergology, Faculty of Medicine, Saarland University, Homburg, Germany.
Albert Joachim OmlorDepartment of Experimental Pneumology and Allergology, Faculty of Medicine, Saarland University, Homburg, Germany.
Isabella TavernaroLeibniz Institute for New Materials, Saarland University, Campus D2 2, D-66123, Saarbrücken, Germany.
Annette KraegelohLeibniz Institute for New Materials, Saarland University, Campus D2 2, D-66123, Saarbrücken, Germany.
Ralf KautenburgerInstitute of Inorganic Solid State Chemistry, Campus Dudweiler, Saarland University, Saarbrücken, Germany.
Guido KickelbickInstitute of Inorganic Solid State Chemistry, Campus Dudweiler, Saarland University, Saarbrücken, Germany.
Andreas BeilhackDepartment of Internal Medicine II, University Hospital, Interdisciplinary Center for Clinical Research Laboratory for Experimental Stem Cell Transplantation, Würzburg, Germany.
Markus BischoffInstitute of Medical Microbiology and Hygiene, Saarland University Hospital, Homburg, Germany.
Juliane NguyenDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, New York, USA.
Martina SesterTransplant and Infection Immunology, Faculty of Medicine, Saarland University, Homburg, Germany.
Robert BalsDepartment of Internal Medicine, Pneumology, Allergology, and Respiratory Critical Care Medicine, Faculty of Medicine, Saarland University, Homburg, Germany.
Quoc Thai DinhDepartment of Experimental Pneumology and Allergology, Faculty of Medicine, Saarland University, Homburg, Germany. thai.dinh@uks.eu.
Saarland University · DELeibniz-Institute for New Materials · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTitanium dioxide nanoparticles (TiO

methodsFor the purpose of the study, female BALB/c mice with or without asthma were intranasally administered with TiO

resultsAccording to the results, the mice receiving OVA alone or OVA plus TiO

conclusionBased on the findings of the current study, intranasally or inhalation exposure to high-dose nanosized TiO

Indexed as

Administration, IntranasalAnimalsAsthmaBronchial HyperreactivityBronchoalveolar Lavage FluidCytokinesEosinophilsFemaleInhalation ExposureMiceMice, Inbred BALB CNanoparticlesOvalbuminRespiratory Function TestsTitaniumT-Lymphocytes, Helper-InducerCytokinesOvalbuminTitaniumtitanium dioxideAirway inflammationAsthmaHyperresponsiveness, systemic uptakeOvalbuminTitanium dioxide nanoparticles

Identifiers

PMID32616045
PMCPMC7331175
OpenAlexW3039099708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.