Evidence map›Paper›PMID 32616026›Full record

ArticleTrials2020

Single dose versus 24 h antibiotic prophylaxis in reduction mammaplasty: study protocol for a randomized controlled trial.

Daniela Francescato Veiga, Edgard da Silva Garcia, José Wilson Moreira-Filho, Evelyne Borges de Mattos Andrade, Yara Juliano, Joel Veiga-Filho, Lydia Masako Ferreira

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04079686 (Single Dose Versus 24 Hours Antibiotic Prophylaxis in Reduction Mammaplasty), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04079686 nacompletednot on this map

Single Dose Versus 24 Hours Antibiotic Prophylaxis in Reduction Mammaplasty: a Randomized Clinical Trial

TypeinterventionalSponsorDaniela Francescato VeigaRan2019 to 2024Enrolled146ConditionsPlastic Surgery, Mammaplasty, Anti-bacterial Agents, ProphylaxisArmsCephazolin, Sterile saline
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Daniela Francescato VeigaTranslational Surgery Graduate Program, Universidade Federal de São Paulo, São Paulo, Brazil. danielafveiga@gmail.com.ORCID http://orcid.org/0000-0002-8713-2940
Edgard da Silva GarciaDivision of Plastic Surgery, Department of Surgery, Universidade do Vale do Sapucaí, Pouso Alegre, Brazil.
José Wilson Moreira-FilhoDivision of Plastic Surgery, Department of Surgery, Universidade do Vale do Sapucaí, Pouso Alegre, Brazil.
Evelyne Borges de Mattos AndradeDivision of Plastic Surgery, Department of Surgery, Universidade do Vale do Sapucaí, Pouso Alegre, Brazil.
Yara JulianoDepartment of Bioestatistics, Universidade Federal de São Paulo, and Universidade de Santo Amaro, São Paulo, Brazil.
Joel Veiga-FilhoDivision of Plastic Surgery, Department of Surgery, Universidade do Vale do Sapucaí, Pouso Alegre, Brazil.
Lydia Masako FerreiraTranslational Surgery Graduate Program, Universidade Federal de São Paulo, São Paulo, Brazil.
Universidade do Vale do Sapucaí · BRUniversidade de Santo Amaro · BRUniversidade Federal de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico grant 302239/2018-9
6 · The paper itself

Abstract

backgroundReduction mammaplasty is among the most commonly performed procedures in plastic surgery. Antibiotics are widely prescribed, on an empirical basis, to prevent surgical site infections. However, there is a lack of evidence to support its use. This trial aims to compare the influence of the use of prophylatic antibiotics as a single dose or for 24 h on surgical site infection rates following reduction mammaplasty.

methodsRandomized trial of non-inferiority, with two parallel groups. A total of 146 breast hypertrophy patients, with reduction mammaplasty already scheduled, will be enrolled. Patients will be randomly allocated to the placebo group that will receive antibiotics only at the anesthesia induction (n = 73) or to the antibiotics group that will receive antibiotics at the anesthesia induction and for 24 h (n = 73). None of the patients will receive antibiotics after hospital discharge. Patients will be followed-up weekly, for 30 days, regarding surgical site infection. The Centers for Disease Control and Prevention criteria will be applied. A statistical analysis of the data will be performed. DISCUSSION: Previous studies have demonstrated a decrease in infection rates after reduction mammaplasty when antibiotic prophylaxis was used, compared to the use of no antibiotics. However, the duration of antibiotic prophylaxis remains a point to be clarified. This study will test the hypothesis that maintaining the use of antibiotics for 24 h does not reduce infection rates compared to the use of a single preoperative dose.

trial registrationClinicaltrials.gov NCT04079686 . Registered on September 6, 2019.

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisBrazilEquivalence Trials as TopicFemaleHumansMammaplastyRandomized Controlled Trials as TopicSurgical Wound InfectionAnti-Bacterial AgentsAnti-bacterial agentsMammaplastyPlastic surgeryProphylaxisWound infection

Identifiers

PMID32616026
PMCPMC7331275
OpenAlexW3039154204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.